Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study
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Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study. / Aglago, Elom K.; Mayén, Ana Lucia; Knaze, Viktoria; Freisling, Heinz; Fedirko, Veronika; Hughes, David J.; Jiao, Li; Eriksen, Anne Kirstine; Tjønneland, Anne; Boutron-Ruault, Marie Christine; Rothwell, Joseph A.; Severi, Gianluca; Kaaks, Rudolf; Katzke, Verena; Schulze, Matthias B.; Birukov, Anna; Palli, Domenico; Sieri, Sabina; De Magistris, Maria Santucci; Tumino, Rosario; Ricceri, Fulvio; Bueno-De-Mesquita, Bas; Derksen, Jeroen W.G.; Skeie, Guri; Gram, Inger Torhild; Sandanger, Torkjel; Quirós, J. Ramón; Luján-Barroso, Leila; Sánchez, Maria Jose; Amiano, Pilar; Chirlaque, María Dolores; Gurrea, Aurelio Barricarte; Johansson, Ingegerd; Manjer, Jonas; Perez-Cornago, Aurora; Weiderpass, Elisabete; Gunter, Marc J.; Heath, Alicia K.; Schalkwijk, Casper G.; Jenab, Mazda.
I: Nutrients, Bind 13, Nr. 9, 3132, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study
AU - Aglago, Elom K.
AU - Mayén, Ana Lucia
AU - Knaze, Viktoria
AU - Freisling, Heinz
AU - Fedirko, Veronika
AU - Hughes, David J.
AU - Jiao, Li
AU - Eriksen, Anne Kirstine
AU - Tjønneland, Anne
AU - Boutron-Ruault, Marie Christine
AU - Rothwell, Joseph A.
AU - Severi, Gianluca
AU - Kaaks, Rudolf
AU - Katzke, Verena
AU - Schulze, Matthias B.
AU - Birukov, Anna
AU - Palli, Domenico
AU - Sieri, Sabina
AU - De Magistris, Maria Santucci
AU - Tumino, Rosario
AU - Ricceri, Fulvio
AU - Bueno-De-Mesquita, Bas
AU - Derksen, Jeroen W.G.
AU - Skeie, Guri
AU - Gram, Inger Torhild
AU - Sandanger, Torkjel
AU - Quirós, J. Ramón
AU - Luján-Barroso, Leila
AU - Sánchez, Maria Jose
AU - Amiano, Pilar
AU - Chirlaque, María Dolores
AU - Gurrea, Aurelio Barricarte
AU - Johansson, Ingegerd
AU - Manjer, Jonas
AU - Perez-Cornago, Aurora
AU - Weiderpass, Elisabete
AU - Gunter, Marc J.
AU - Heath, Alicia K.
AU - Schalkwijk, Casper G.
AU - Jenab, Mazda
N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: N"-carboxy-methyllysine (CML), Nԑ-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89–1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.
AB - Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: N"-carboxy-methyllysine (CML), Nԑ-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89–1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.
KW - Advanced glycation end-products
KW - Colorectal cancer
KW - Dietary exposure
KW - Dietary glycation compounds
U2 - 10.3390/nu13093132
DO - 10.3390/nu13093132
M3 - Journal article
C2 - 34579010
AN - SCOPUS:85115008015
VL - 13
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 9
M1 - 3132
ER -
ID: 286489052