Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study

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Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study. / Aglago, Elom K.; Mayén, Ana Lucia; Knaze, Viktoria; Freisling, Heinz; Fedirko, Veronika; Hughes, David J.; Jiao, Li; Eriksen, Anne Kirstine; Tjønneland, Anne; Boutron-Ruault, Marie Christine; Rothwell, Joseph A.; Severi, Gianluca; Kaaks, Rudolf; Katzke, Verena; Schulze, Matthias B.; Birukov, Anna; Palli, Domenico; Sieri, Sabina; De Magistris, Maria Santucci; Tumino, Rosario; Ricceri, Fulvio; Bueno-De-Mesquita, Bas; Derksen, Jeroen W.G.; Skeie, Guri; Gram, Inger Torhild; Sandanger, Torkjel; Quirós, J. Ramón; Luján-Barroso, Leila; Sánchez, Maria Jose; Amiano, Pilar; Chirlaque, María Dolores; Gurrea, Aurelio Barricarte; Johansson, Ingegerd; Manjer, Jonas; Perez-Cornago, Aurora; Weiderpass, Elisabete; Gunter, Marc J.; Heath, Alicia K.; Schalkwijk, Casper G.; Jenab, Mazda.

I: Nutrients, Bind 13, Nr. 9, 3132, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Aglago, EK, Mayén, AL, Knaze, V, Freisling, H, Fedirko, V, Hughes, DJ, Jiao, L, Eriksen, AK, Tjønneland, A, Boutron-Ruault, MC, Rothwell, JA, Severi, G, Kaaks, R, Katzke, V, Schulze, MB, Birukov, A, Palli, D, Sieri, S, De Magistris, MS, Tumino, R, Ricceri, F, Bueno-De-Mesquita, B, Derksen, JWG, Skeie, G, Gram, IT, Sandanger, T, Quirós, JR, Luján-Barroso, L, Sánchez, MJ, Amiano, P, Chirlaque, MD, Gurrea, AB, Johansson, I, Manjer, J, Perez-Cornago, A, Weiderpass, E, Gunter, MJ, Heath, AK, Schalkwijk, CG & Jenab, M 2021, 'Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study', Nutrients, bind 13, nr. 9, 3132. https://doi.org/10.3390/nu13093132

APA

Aglago, E. K., Mayén, A. L., Knaze, V., Freisling, H., Fedirko, V., Hughes, D. J., Jiao, L., Eriksen, A. K., Tjønneland, A., Boutron-Ruault, M. C., Rothwell, J. A., Severi, G., Kaaks, R., Katzke, V., Schulze, M. B., Birukov, A., Palli, D., Sieri, S., De Magistris, M. S., ... Jenab, M. (2021). Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study. Nutrients, 13(9), [3132]. https://doi.org/10.3390/nu13093132

Vancouver

Aglago EK, Mayén AL, Knaze V, Freisling H, Fedirko V, Hughes DJ o.a. Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study. Nutrients. 2021;13(9). 3132. https://doi.org/10.3390/nu13093132

Author

Aglago, Elom K. ; Mayén, Ana Lucia ; Knaze, Viktoria ; Freisling, Heinz ; Fedirko, Veronika ; Hughes, David J. ; Jiao, Li ; Eriksen, Anne Kirstine ; Tjønneland, Anne ; Boutron-Ruault, Marie Christine ; Rothwell, Joseph A. ; Severi, Gianluca ; Kaaks, Rudolf ; Katzke, Verena ; Schulze, Matthias B. ; Birukov, Anna ; Palli, Domenico ; Sieri, Sabina ; De Magistris, Maria Santucci ; Tumino, Rosario ; Ricceri, Fulvio ; Bueno-De-Mesquita, Bas ; Derksen, Jeroen W.G. ; Skeie, Guri ; Gram, Inger Torhild ; Sandanger, Torkjel ; Quirós, J. Ramón ; Luján-Barroso, Leila ; Sánchez, Maria Jose ; Amiano, Pilar ; Chirlaque, María Dolores ; Gurrea, Aurelio Barricarte ; Johansson, Ingegerd ; Manjer, Jonas ; Perez-Cornago, Aurora ; Weiderpass, Elisabete ; Gunter, Marc J. ; Heath, Alicia K. ; Schalkwijk, Casper G. ; Jenab, Mazda. / Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study. I: Nutrients. 2021 ; Bind 13, Nr. 9.

Bibtex

@article{2358bf79171c464ebf12715ab2146282,

title = "Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study",

abstract = "Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: N{"}-carboxy-methyllysine (CML), Nԑ-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89–1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.",

keywords = "Advanced glycation end-products, Colorectal cancer, Dietary exposure, Dietary glycation compounds",

author = "Aglago, {Elom K.} and May{\'e}n, {Ana Lucia} and Viktoria Knaze and Heinz Freisling and Veronika Fedirko and Hughes, {David J.} and Li Jiao and Eriksen, {Anne Kirstine} and Anne Tj{\o}nneland and Boutron-Ruault, {Marie Christine} and Rothwell, {Joseph A.} and Gianluca Severi and Rudolf Kaaks and Verena Katzke and Schulze, {Matthias B.} and Anna Birukov and Domenico Palli and Sabina Sieri and {De Magistris}, {Maria Santucci} and Rosario Tumino and Fulvio Ricceri and Bas Bueno-De-Mesquita and Derksen, {Jeroen W.G.} and Guri Skeie and Gram, {Inger Torhild} and Torkjel Sandanger and Quir{\'o}s, {J. Ram{\'o}n} and Leila Luj{\'a}n-Barroso and S{\'a}nchez, {Maria Jose} and Pilar Amiano and Chirlaque, {Mar{\'i}a Dolores} and Gurrea, {Aurelio Barricarte} and Ingegerd Johansson and Jonas Manjer and Aurora Perez-Cornago and Elisabete Weiderpass and Gunter, {Marc J.} and Heath, {Alicia K.} and Schalkwijk, {Casper G.} and Mazda Jenab",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

doi = "10.3390/nu13093132",

language = "English",

volume = "13",

journal = "Nutrients",

issn = "2072-6643",

publisher = "M D P I AG",

number = "9",

}

RIS

TY - JOUR

T1 - Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study

AU - Aglago, Elom K.

AU - Mayén, Ana Lucia

AU - Knaze, Viktoria

AU - Freisling, Heinz

AU - Fedirko, Veronika

AU - Hughes, David J.

AU - Jiao, Li

AU - Eriksen, Anne Kirstine

AU - Tjønneland, Anne

AU - Boutron-Ruault, Marie Christine

AU - Rothwell, Joseph A.

AU - Severi, Gianluca

AU - Kaaks, Rudolf

AU - Katzke, Verena

AU - Schulze, Matthias B.

AU - Birukov, Anna

AU - Palli, Domenico

AU - Sieri, Sabina

AU - De Magistris, Maria Santucci

AU - Tumino, Rosario

AU - Ricceri, Fulvio

AU - Bueno-De-Mesquita, Bas

AU - Derksen, Jeroen W.G.

AU - Skeie, Guri

AU - Gram, Inger Torhild

AU - Sandanger, Torkjel

AU - Quirós, J. Ramón

AU - Luján-Barroso, Leila

AU - Sánchez, Maria Jose

AU - Amiano, Pilar

AU - Chirlaque, María Dolores

AU - Gurrea, Aurelio Barricarte

AU - Johansson, Ingegerd

AU - Manjer, Jonas

AU - Perez-Cornago, Aurora

AU - Weiderpass, Elisabete

AU - Gunter, Marc J.

AU - Heath, Alicia K.

AU - Schalkwijk, Casper G.

AU - Jenab, Mazda

PY - 2021

Y1 - 2021

N2 - Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: N"-carboxy-methyllysine (CML), Nԑ-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89–1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.

AB - Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: N"-carboxy-methyllysine (CML), Nԑ-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89–1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.

KW - Advanced glycation end-products

KW - Colorectal cancer

KW - Dietary exposure

KW - Dietary glycation compounds

U2 - 10.3390/nu13093132

DO - 10.3390/nu13093132

M3 - Journal article

C2 - 34579010

AN - SCOPUS:85115008015

VL - 13

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 9

M1 - 3132

ER -

ID: 286489052