Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer. / Grenville, Zoe S.; Noor, Urwah; His, Mathilde; Viallon, Vivian; Rinaldi, Sabina; Aglago, Elom K.; Amiano, Pilar; Brunkwall, Louise; Dolores Chirlaque, Maria; Drake, Isabel; Eichelmann, Fabian; Freisling, Heinz; Grioni, Sara; Heath, Alicia K.; Kaaks, Rudolf; Katzke, Verena; Mayen-Chacon, Ana-Lucia; Milani, Lorenzo; Moreno-Iribas, Conchi; Pala, Valeria; Olsen, Anja; Sanchez, Maria-Jose; Schulze, Matthias B.; Tjonneland, Anne; Tsilidis, Konstantinos K.; Weiderpass, Elisabete; Winkvist, Anna; Zamora-Ros, Raul; Key, Timothy J.; Smith-Byrne, Karl; Travis, Ruth C.; Schmidt, Julie A.

I: Nutrients, Bind 14, Nr. 16, 3306, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Grenville, ZS, Noor, U, His, M, Viallon, V, Rinaldi, S, Aglago, EK, Amiano, P, Brunkwall, L, Dolores Chirlaque, M, Drake, I, Eichelmann, F, Freisling, H, Grioni, S, Heath, AK, Kaaks, R, Katzke, V, Mayen-Chacon, A-L, Milani, L, Moreno-Iribas, C, Pala, V, Olsen, A, Sanchez, M-J, Schulze, MB, Tjonneland, A, Tsilidis, KK, Weiderpass, E, Winkvist, A, Zamora-Ros, R, Key, TJ, Smith-Byrne, K, Travis, RC & Schmidt, JA 2022, 'Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer', Nutrients, bind 14, nr. 16, 3306. https://doi.org/10.3390/nu14163306

APA

Grenville, Z. S., Noor, U., His, M., Viallon, V., Rinaldi, S., Aglago, E. K., Amiano, P., Brunkwall, L., Dolores Chirlaque, M., Drake, I., Eichelmann, F., Freisling, H., Grioni, S., Heath, A. K., Kaaks, R., Katzke, V., Mayen-Chacon, A-L., Milani, L., Moreno-Iribas, C., ... Schmidt, J. A. (2022). Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer. Nutrients, 14(16), [3306]. https://doi.org/10.3390/nu14163306

Vancouver

Grenville ZS, Noor U, His M, Viallon V, Rinaldi S, Aglago EK o.a. Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer. Nutrients. 2022;14(16). 3306. https://doi.org/10.3390/nu14163306

Author

Grenville, Zoe S. ; Noor, Urwah ; His, Mathilde ; Viallon, Vivian ; Rinaldi, Sabina ; Aglago, Elom K. ; Amiano, Pilar ; Brunkwall, Louise ; Dolores Chirlaque, Maria ; Drake, Isabel ; Eichelmann, Fabian ; Freisling, Heinz ; Grioni, Sara ; Heath, Alicia K. ; Kaaks, Rudolf ; Katzke, Verena ; Mayen-Chacon, Ana-Lucia ; Milani, Lorenzo ; Moreno-Iribas, Conchi ; Pala, Valeria ; Olsen, Anja ; Sanchez, Maria-Jose ; Schulze, Matthias B. ; Tjonneland, Anne ; Tsilidis, Konstantinos K. ; Weiderpass, Elisabete ; Winkvist, Anna ; Zamora-Ros, Raul ; Key, Timothy J. ; Smith-Byrne, Karl ; Travis, Ruth C. ; Schmidt, Julie A. / Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer. I: Nutrients. 2022 ; Bind 14, Nr. 16.

Bibtex

@article{8795c00ef4334647a313caa16e8c01f4,
title = "Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer",
abstract = "Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern 1), acylcarnitines C18:1 and C18:2, glutamate, ornithine, and taurine (Pattern 2), and 8 lysophosphatidylcholines (Pattern 3). In a two-stage cross-sectional discovery (n = 2524) and validation (n = 518) design containing 3042 men free of cancer in EPIC, we estimated the associations of 24 dietary and lifestyle variables with each pattern and the contributing individual metabolites. Associations statistically significant after both correction for multiple testing (False Discovery Rate = 0.05) in the discovery set and at p < 0.05 in the validation set were considered robust. Intakes of alcohol, total fish products, and its subsets total fish and lean fish were positively associated with Pattern 1. Body mass index (BMI) was positively associated with Pattern 2, which appeared to be driven by a strong positive BMI-glutamate association. Finally, both BMI and fatty fish were inversely associated with Pattern 3. In conclusion, these results indicate associations of fish and its subtypes, alcohol, and BMI with metabolite patterns that are inversely associated with risk of aggressive prostate cancer.",
keywords = "metabolites, diet, prostate cancer, cross-sectional, BODY-MASS INDEX, DIFFERENTIATED THYROID-CARCINOMA, ALCOHOL-CONSUMPTION, TARGETED METABOLOMICS, FATTY-ACIDS, FISH-OIL, RISK, PRODUCTS, VALIDITY, COHORT",
author = "Grenville, {Zoe S.} and Urwah Noor and Mathilde His and Vivian Viallon and Sabina Rinaldi and Aglago, {Elom K.} and Pilar Amiano and Louise Brunkwall and {Dolores Chirlaque}, Maria and Isabel Drake and Fabian Eichelmann and Heinz Freisling and Sara Grioni and Heath, {Alicia K.} and Rudolf Kaaks and Verena Katzke and Ana-Lucia Mayen-Chacon and Lorenzo Milani and Conchi Moreno-Iribas and Valeria Pala and Anja Olsen and Maria-Jose Sanchez and Schulze, {Matthias B.} and Anne Tjonneland and Tsilidis, {Konstantinos K.} and Elisabete Weiderpass and Anna Winkvist and Raul Zamora-Ros and Key, {Timothy J.} and Karl Smith-Byrne and Travis, {Ruth C.} and Schmidt, {Julie A.}",
year = "2022",
doi = "10.3390/nu14163306",
language = "English",
volume = "14",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "16",

}

RIS

TY - JOUR

T1 - Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer

AU - Grenville, Zoe S.

AU - Noor, Urwah

AU - His, Mathilde

AU - Viallon, Vivian

AU - Rinaldi, Sabina

AU - Aglago, Elom K.

AU - Amiano, Pilar

AU - Brunkwall, Louise

AU - Dolores Chirlaque, Maria

AU - Drake, Isabel

AU - Eichelmann, Fabian

AU - Freisling, Heinz

AU - Grioni, Sara

AU - Heath, Alicia K.

AU - Kaaks, Rudolf

AU - Katzke, Verena

AU - Mayen-Chacon, Ana-Lucia

AU - Milani, Lorenzo

AU - Moreno-Iribas, Conchi

AU - Pala, Valeria

AU - Olsen, Anja

AU - Sanchez, Maria-Jose

AU - Schulze, Matthias B.

AU - Tjonneland, Anne

AU - Tsilidis, Konstantinos K.

AU - Weiderpass, Elisabete

AU - Winkvist, Anna

AU - Zamora-Ros, Raul

AU - Key, Timothy J.

AU - Smith-Byrne, Karl

AU - Travis, Ruth C.

AU - Schmidt, Julie A.

PY - 2022

Y1 - 2022

N2 - Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern 1), acylcarnitines C18:1 and C18:2, glutamate, ornithine, and taurine (Pattern 2), and 8 lysophosphatidylcholines (Pattern 3). In a two-stage cross-sectional discovery (n = 2524) and validation (n = 518) design containing 3042 men free of cancer in EPIC, we estimated the associations of 24 dietary and lifestyle variables with each pattern and the contributing individual metabolites. Associations statistically significant after both correction for multiple testing (False Discovery Rate = 0.05) in the discovery set and at p < 0.05 in the validation set were considered robust. Intakes of alcohol, total fish products, and its subsets total fish and lean fish were positively associated with Pattern 1. Body mass index (BMI) was positively associated with Pattern 2, which appeared to be driven by a strong positive BMI-glutamate association. Finally, both BMI and fatty fish were inversely associated with Pattern 3. In conclusion, these results indicate associations of fish and its subtypes, alcohol, and BMI with metabolite patterns that are inversely associated with risk of aggressive prostate cancer.

AB - Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern 1), acylcarnitines C18:1 and C18:2, glutamate, ornithine, and taurine (Pattern 2), and 8 lysophosphatidylcholines (Pattern 3). In a two-stage cross-sectional discovery (n = 2524) and validation (n = 518) design containing 3042 men free of cancer in EPIC, we estimated the associations of 24 dietary and lifestyle variables with each pattern and the contributing individual metabolites. Associations statistically significant after both correction for multiple testing (False Discovery Rate = 0.05) in the discovery set and at p < 0.05 in the validation set were considered robust. Intakes of alcohol, total fish products, and its subsets total fish and lean fish were positively associated with Pattern 1. Body mass index (BMI) was positively associated with Pattern 2, which appeared to be driven by a strong positive BMI-glutamate association. Finally, both BMI and fatty fish were inversely associated with Pattern 3. In conclusion, these results indicate associations of fish and its subtypes, alcohol, and BMI with metabolite patterns that are inversely associated with risk of aggressive prostate cancer.

KW - metabolites

KW - diet

KW - prostate cancer

KW - cross-sectional

KW - BODY-MASS INDEX

KW - DIFFERENTIATED THYROID-CARCINOMA

KW - ALCOHOL-CONSUMPTION

KW - TARGETED METABOLOMICS

KW - FATTY-ACIDS

KW - FISH-OIL

KW - RISK

KW - PRODUCTS

KW - VALIDITY

KW - COHORT

U2 - 10.3390/nu14163306

DO - 10.3390/nu14163306

M3 - Journal article

C2 - 36014812

VL - 14

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 16

M1 - 3306

ER -

ID: 318704975