Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Diagnosis of multiple sclerosis : 2017 revisions of the McDonald criteria. / Thompson, Alan J; Banwell, Brenda L; Barkhof, Frederik; Carroll, William M; Coetzee, Timothy; Comi, Giancarlo; Correale, Jorge; Fazekas, Franz; Filippi, Massimo; Freedman, Mark S; Fujihara, Kazuo; Galetta, Steven L; Hartung, Hans Peter; Kappos, Ludwig; Lublin, Fred D; Marrie, Ruth Ann; Miller, Aaron E; Miller, David H; Montalban, Xavier; Mowry, Ellen M; Sorensen, Per Soelberg; Tintoré, Mar; Traboulsee, Anthony L; Trojano, Maria; Uitdehaag, Bernard M J; Vukusic, Sandra; Waubant, Emmanuelle; Weinshenker, Brian G; Reingold, Stephen C; Cohen, Jeffrey A.
I: Lancet Neurology, Bind 17, Nr. 2, 2018, s. 162-173.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Diagnosis of multiple sclerosis
T2 - 2017 revisions of the McDonald criteria
AU - Thompson, Alan J
AU - Banwell, Brenda L
AU - Barkhof, Frederik
AU - Carroll, William M
AU - Coetzee, Timothy
AU - Comi, Giancarlo
AU - Correale, Jorge
AU - Fazekas, Franz
AU - Filippi, Massimo
AU - Freedman, Mark S
AU - Fujihara, Kazuo
AU - Galetta, Steven L
AU - Hartung, Hans Peter
AU - Kappos, Ludwig
AU - Lublin, Fred D
AU - Marrie, Ruth Ann
AU - Miller, Aaron E
AU - Miller, David H
AU - Montalban, Xavier
AU - Mowry, Ellen M
AU - Sorensen, Per Soelberg
AU - Tintoré, Mar
AU - Traboulsee, Anthony L
AU - Trojano, Maria
AU - Uitdehaag, Bernard M J
AU - Vukusic, Sandra
AU - Waubant, Emmanuelle
AU - Weinshenker, Brian G
AU - Reingold, Stephen C
AU - Cohen, Jeffrey A
N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.
PY - 2018
Y1 - 2018
N2 - The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. The International Panel on Diagnosis of Multiple Sclerosis reviewed the 2010 McDonald criteria and recommended revisions. The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation. The following changes were made: in patients with a typical clinically isolated syndrome and clinical or MRI demonstration of dissemination in space, the presence of CSF-specific oligoclonal bands allows a diagnosis of multiple sclerosis; symptomatic lesions can be used to demonstrate dissemination in space or time in patients with supratentorial, infratentorial, or spinal cord syndrome; and cortical lesions can be used to demonstrate dissemination in space. Research to further refine the criteria should focus on optic nerve involvement, validation in diverse populations, and incorporation of advanced imaging, neurophysiological, and body fluid markers.
AB - The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. The International Panel on Diagnosis of Multiple Sclerosis reviewed the 2010 McDonald criteria and recommended revisions. The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation. The following changes were made: in patients with a typical clinically isolated syndrome and clinical or MRI demonstration of dissemination in space, the presence of CSF-specific oligoclonal bands allows a diagnosis of multiple sclerosis; symptomatic lesions can be used to demonstrate dissemination in space or time in patients with supratentorial, infratentorial, or spinal cord syndrome; and cortical lesions can be used to demonstrate dissemination in space. Research to further refine the criteria should focus on optic nerve involvement, validation in diverse populations, and incorporation of advanced imaging, neurophysiological, and body fluid markers.
KW - Adult
KW - Aged
KW - Cerebral Cortex/pathology
KW - Demyelinating Diseases/diagnosis
KW - Humans
KW - Magnetic Resonance Imaging
KW - Middle Aged
KW - Multiple Sclerosis/diagnosis
KW - Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging
KW - Neurologic Examination
KW - Oligoclonal Bands/cerebrospinal fluid
KW - Spinal Cord/pathology
U2 - 10.1016/S1474-4422(17)30470-2
DO - 10.1016/S1474-4422(17)30470-2
M3 - Review
C2 - 29275977
VL - 17
SP - 162
EP - 173
JO - The Lancet Neurology
JF - The Lancet Neurology
SN - 1474-4422
IS - 2
ER -
ID: 218522231