Developmental changes of rRNA ribose methylations in the mouse

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Standard

Developmental changes of rRNA ribose methylations in the mouse. / Hebras, Jade; Krogh, Nicolai; Marty, Virginie; Nielsen, Henrik; Cavaillé, Jérôme.

I: RNA Biology, Bind 17, Nr. 1, 2020, s. 150-164.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hebras, J, Krogh, N, Marty, V, Nielsen, H & Cavaillé, J 2020, 'Developmental changes of rRNA ribose methylations in the mouse', RNA Biology, bind 17, nr. 1, s. 150-164. https://doi.org/10.1080/15476286.2019.1670598

APA

Hebras, J., Krogh, N., Marty, V., Nielsen, H., & Cavaillé, J. (2020). Developmental changes of rRNA ribose methylations in the mouse. RNA Biology, 17(1), 150-164. https://doi.org/10.1080/15476286.2019.1670598

Vancouver

Hebras J, Krogh N, Marty V, Nielsen H, Cavaillé J. Developmental changes of rRNA ribose methylations in the mouse. RNA Biology. 2020;17(1):150-164. https://doi.org/10.1080/15476286.2019.1670598

Author

Hebras, Jade ; Krogh, Nicolai ; Marty, Virginie ; Nielsen, Henrik ; Cavaillé, Jérôme. / Developmental changes of rRNA ribose methylations in the mouse. I: RNA Biology. 2020 ; Bind 17, Nr. 1. s. 150-164.

Bibtex

@article{1f747ad7a6714d56a1dcf4b09ab69fae,
title = "Developmental changes of rRNA ribose methylations in the mouse",
abstract = "A sequencing-based profiling method (RiboMeth-seq) for ribose methylations was used to study methylation patterns in mouse adult tissues and during development. In contrast to previous reports based on studies of human cancer cell lines, almost all methylation sites were close to fully methylated in adult tissues. A subset of sites was differentially modified in developing tissues compared to their adult counterparts and showed clear developmental dynamics. This provides the first evidence for ribosome heterogeneity at the level of rRNA modifications during mouse development. In a prominent example, the expression levels of SNORD78 during development appeared to be regulated by alternative splicing of the Gas5 host-gene and to correlate with the methylation level of its target site at LSU-G4593. The results are discussed in the context of the specialized ribosome hypothesis.",
author = "Jade Hebras and Nicolai Krogh and Virginie Marty and Henrik Nielsen and J{\'e}r{\^o}me Cavaill{\'e}",
year = "2020",
doi = "10.1080/15476286.2019.1670598",
language = "English",
volume = "17",
pages = "150--164",
journal = "R N A Biology",
issn = "1547-6286",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - Developmental changes of rRNA ribose methylations in the mouse

AU - Hebras, Jade

AU - Krogh, Nicolai

AU - Marty, Virginie

AU - Nielsen, Henrik

AU - Cavaillé, Jérôme

PY - 2020

Y1 - 2020

N2 - A sequencing-based profiling method (RiboMeth-seq) for ribose methylations was used to study methylation patterns in mouse adult tissues and during development. In contrast to previous reports based on studies of human cancer cell lines, almost all methylation sites were close to fully methylated in adult tissues. A subset of sites was differentially modified in developing tissues compared to their adult counterparts and showed clear developmental dynamics. This provides the first evidence for ribosome heterogeneity at the level of rRNA modifications during mouse development. In a prominent example, the expression levels of SNORD78 during development appeared to be regulated by alternative splicing of the Gas5 host-gene and to correlate with the methylation level of its target site at LSU-G4593. The results are discussed in the context of the specialized ribosome hypothesis.

AB - A sequencing-based profiling method (RiboMeth-seq) for ribose methylations was used to study methylation patterns in mouse adult tissues and during development. In contrast to previous reports based on studies of human cancer cell lines, almost all methylation sites were close to fully methylated in adult tissues. A subset of sites was differentially modified in developing tissues compared to their adult counterparts and showed clear developmental dynamics. This provides the first evidence for ribosome heterogeneity at the level of rRNA modifications during mouse development. In a prominent example, the expression levels of SNORD78 during development appeared to be regulated by alternative splicing of the Gas5 host-gene and to correlate with the methylation level of its target site at LSU-G4593. The results are discussed in the context of the specialized ribosome hypothesis.

U2 - 10.1080/15476286.2019.1670598

DO - 10.1080/15476286.2019.1670598

M3 - Journal article

C2 - 31566069

VL - 17

SP - 150

EP - 164

JO - R N A Biology

JF - R N A Biology

SN - 1547-6286

IS - 1

ER -

ID: 228734348