Determinants of occurrence and survival after sudden cardiac arrest–A European perspective: The ESCAPE-NET project
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Determinants of occurrence and survival after sudden cardiac arrest–A European perspective : The ESCAPE-NET project. / Empana, Jean Philippe; Blom, Marieke T.; Bӧttiger, Bernd W.; Dagres, Nikolaos; Dekker, Jacqueline M.; Gislason, Gunnar; Jouven, Xavier; Meitinger, Thomas; Ristagno, Giuseppe; Schwartz, Peter J.; Jonsson, Martin; Tfelt-Hansen, Jacob; Truhlar, Anatolij; Tan, Hanno L.; on behalf of the ESCAPE-NET Investigators.
I: Resuscitation, Bind 124, 01.03.2018, s. 7-13.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Determinants of occurrence and survival after sudden cardiac arrest–A European perspective
T2 - The ESCAPE-NET project
AU - Empana, Jean Philippe
AU - Blom, Marieke T.
AU - Bӧttiger, Bernd W.
AU - Dagres, Nikolaos
AU - Dekker, Jacqueline M.
AU - Gislason, Gunnar
AU - Jouven, Xavier
AU - Meitinger, Thomas
AU - Ristagno, Giuseppe
AU - Schwartz, Peter J.
AU - Jonsson, Martin
AU - Tfelt-Hansen, Jacob
AU - Truhlar, Anatolij
AU - Tan, Hanno L.
AU - on behalf of the ESCAPE-NET Investigators
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Aims The ESCAPE-NET project (“European Sudden Cardiac Arrest network– towards Prevention, Education and New Effective Treatments”) aims to study: (1) risk factors and mechanisms for the occurrence of sudden cardiac arrest (SCA) in the population, and (2) risk factors and treatment strategies for survival after SCA on a European scale. Methods This is an Horizon2020 funded program of the European Union, performed by a European public-private consortium of 16 partners across 10 EU countries. There are 11 deep-phenotyped SCA cohorts for the study of risk factors and treatment strategies for survival after SCA, and 5 deep-phenotyped observational prospective population cohorts for the study of risk factors for occurrence of SCA. Personalized risk scores for predicting SCA onset and for predicting survival after SCA will be derived and validated. Results The 11 clinical studies with SCA cases comprise 85,790 SCA cases; the 5 observational prospective population cohorts include 53,060 subjects. A total of 15,000 SCA samples will be genotyped for common and rare variants at the Helmholtz Zentrum München (Germany) using the Illumina Global Screening Array which contains > 770,000 SNPs, and after imputation, a database of an estimated > 9 million variants will be available for genome wide association studies. Standardization of risk factors definition and outcomes is ongoing. An Executive Committee has been created along with a Collaboration Policy document. Conclusion ESCAPE-NET will complement ongoing efforts on SCA outside Europe and within Europe including the EuReCa project.
AB - Aims The ESCAPE-NET project (“European Sudden Cardiac Arrest network– towards Prevention, Education and New Effective Treatments”) aims to study: (1) risk factors and mechanisms for the occurrence of sudden cardiac arrest (SCA) in the population, and (2) risk factors and treatment strategies for survival after SCA on a European scale. Methods This is an Horizon2020 funded program of the European Union, performed by a European public-private consortium of 16 partners across 10 EU countries. There are 11 deep-phenotyped SCA cohorts for the study of risk factors and treatment strategies for survival after SCA, and 5 deep-phenotyped observational prospective population cohorts for the study of risk factors for occurrence of SCA. Personalized risk scores for predicting SCA onset and for predicting survival after SCA will be derived and validated. Results The 11 clinical studies with SCA cases comprise 85,790 SCA cases; the 5 observational prospective population cohorts include 53,060 subjects. A total of 15,000 SCA samples will be genotyped for common and rare variants at the Helmholtz Zentrum München (Germany) using the Illumina Global Screening Array which contains > 770,000 SNPs, and after imputation, a database of an estimated > 9 million variants will be available for genome wide association studies. Standardization of risk factors definition and outcomes is ongoing. An Executive Committee has been created along with a Collaboration Policy document. Conclusion ESCAPE-NET will complement ongoing efforts on SCA outside Europe and within Europe including the EuReCa project.
KW - Automated external defibrillator
KW - Genetics
KW - Resuscitation
KW - Sudden cardiac arrest
KW - Out-of-Hospital Cardiac Arrest/etiology
KW - Risk Assessment
KW - Comorbidity
KW - Humans
KW - Risk Factors
KW - Death, Sudden, Cardiac/epidemiology
KW - Population Surveillance/methods
KW - Emergency Medical Services/statistics & numerical data
KW - Europe/epidemiology
KW - Cohort Studies
KW - Databases, Factual
UR - http://www.scopus.com/inward/record.url?scp=85039729136&partnerID=8YFLogxK
U2 - 10.1016/j.resuscitation.2017.12.011
DO - 10.1016/j.resuscitation.2017.12.011
M3 - Journal article
C2 - 29246744
AN - SCOPUS:85039729136
VL - 124
SP - 7
EP - 13
JO - Resuscitation
JF - Resuscitation
SN - 0300-9572
ER -
ID: 203873416