Determinants of enhancer and promoter activities of regulatory elements
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Determinants of enhancer and promoter activities of regulatory elements. / Andersson, Robin; Sandelin, Albin.
I: Nature Reviews Genetics, Bind 21, Nr. 2, 2020, s. 71-87.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Determinants of enhancer and promoter activities of regulatory elements
AU - Andersson, Robin
AU - Sandelin, Albin
PY - 2020
Y1 - 2020
N2 - The proper activities of enhancers and gene promoters are essential for coordinated transcription within a cell. Although diverse methodologies have been developed to identify enhancers and promoters, most have tacitly assumed that these elements are distinct. However, studies have unexpectedly shown that regulatory elements may have both enhancer and promoter functions. Here we review these results, focusing on the factors that determine the promoter and/or enhancer activity of regulatory elements. We discuss emerging models that define regulatory elements by accessible DNA and their non-mutually-exclusive abilities to drive transcription initiation (promoter activity) and/or to enhance transcription at other such regions (enhancer activity).
AB - The proper activities of enhancers and gene promoters are essential for coordinated transcription within a cell. Although diverse methodologies have been developed to identify enhancers and promoters, most have tacitly assumed that these elements are distinct. However, studies have unexpectedly shown that regulatory elements may have both enhancer and promoter functions. Here we review these results, focusing on the factors that determine the promoter and/or enhancer activity of regulatory elements. We discuss emerging models that define regulatory elements by accessible DNA and their non-mutually-exclusive abilities to drive transcription initiation (promoter activity) and/or to enhance transcription at other such regions (enhancer activity).
U2 - 10.1038/s41576-019-0173-8
DO - 10.1038/s41576-019-0173-8
M3 - Review
C2 - 31605096
AN - SCOPUS:85074011886
VL - 21
SP - 71
EP - 87
JO - Nature Reviews. Genetics
JF - Nature Reviews. Genetics
SN - 1471-0056
IS - 2
ER -
ID: 230096023