Detecting of breast cancer metastasis by means of regional lymph node sampling during autologous breast reconstruction--a screening of 519 consecutive patients
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Detecting of breast cancer metastasis by means of regional lymph node sampling during autologous breast reconstruction--a screening of 519 consecutive patients. / Andree, Christoph; Schmidt, Volker J; Munder, Beatrix I J; Seidenstücker, Katrin; Behrendt, Philipp; Witzel, Christian; Horch, Raymund E; Andrews, Brian T; Richrath, Philipp.
I: Medical Science Monitor, Bind 18, Nr. 10, 10.2012, s. CR605-10.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Detecting of breast cancer metastasis by means of regional lymph node sampling during autologous breast reconstruction--a screening of 519 consecutive patients
AU - Andree, Christoph
AU - Schmidt, Volker J
AU - Munder, Beatrix I J
AU - Seidenstücker, Katrin
AU - Behrendt, Philipp
AU - Witzel, Christian
AU - Horch, Raymund E
AU - Andrews, Brian T
AU - Richrath, Philipp
PY - 2012/10
Y1 - 2012/10
N2 - BACKGROUND: The internal mammary artery and vein is often used as a site of anastomoses in microvascular breast reconstruction. This area supports lymphatic drainage of the breast and its role in breast cancer metastasis remains unclear. We hypothesize that sampling of internal mammary lymph nodes at the time of microvascular anastomoses preparation may identify persistent or recurrent local disease and mandate the need for additional treatment in this area.MATERIAL/METHODS: A retrospective chart review from 519 patients in the time between January 2006 and September 2009 was performed on all patients who underwent internal mammary lymph node sampling at the time of microvascular breast reconstruction.RESULTS: Microvascular breast reconstruction was performed in 519 patients. Enlarged internal mammary lymph nodes were found and harvested in 195 patients for histological review. Six of 195 (3.08%) were found positive for metastatic disease requiring additional oncologic treatment.CONCLUSIONS: The internal mammary lymphatic drainage system is an important and often underappreciated pathway for breast metastasis. Routine sampling of these lymph nodes at the time of microvascular breast reconstruction is easy to perform and is a useful tool to identify women, who might require additional treatment and increase cancer-free survival.
AB - BACKGROUND: The internal mammary artery and vein is often used as a site of anastomoses in microvascular breast reconstruction. This area supports lymphatic drainage of the breast and its role in breast cancer metastasis remains unclear. We hypothesize that sampling of internal mammary lymph nodes at the time of microvascular anastomoses preparation may identify persistent or recurrent local disease and mandate the need for additional treatment in this area.MATERIAL/METHODS: A retrospective chart review from 519 patients in the time between January 2006 and September 2009 was performed on all patients who underwent internal mammary lymph node sampling at the time of microvascular breast reconstruction.RESULTS: Microvascular breast reconstruction was performed in 519 patients. Enlarged internal mammary lymph nodes were found and harvested in 195 patients for histological review. Six of 195 (3.08%) were found positive for metastatic disease requiring additional oncologic treatment.CONCLUSIONS: The internal mammary lymphatic drainage system is an important and often underappreciated pathway for breast metastasis. Routine sampling of these lymph nodes at the time of microvascular breast reconstruction is easy to perform and is a useful tool to identify women, who might require additional treatment and increase cancer-free survival.
KW - Adult
KW - Aged
KW - Breast Neoplasms/drug therapy
KW - Female
KW - Humans
KW - Lymph Nodes/pathology
KW - Lymphatic Metastasis/diagnosis
KW - Mammaplasty
KW - Mediastinum/pathology
KW - Middle Aged
KW - Neoadjuvant Therapy
KW - Sentinel Lymph Node Biopsy
KW - Transplantation, Autologous
KW - Young Adult
U2 - 10.12659/msm.883486
DO - 10.12659/msm.883486
M3 - Journal article
C2 - 23018353
VL - 18
SP - CR605-10
JO - Medical Science Monitor
JF - Medical Science Monitor
SN - 1234-1010
IS - 10
ER -
ID: 329568910