Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma
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Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma. / Stokholm, Jakob; Thorsen, Jonathan; Blaser, Martin J; Rasmussen, Morten A.; Hjelmsø, Mathis; Shah, Shiraz; Christensen, Emil D.; Chawes, Bo L.; Bønnelykke, Klaus; Brix, Susanne; Mortensen, Martin S.; Brejnrod, Asker; Vestergaard, Gisle; Trivedi, Urvish; Sørensen, Søren J.; Bisgaard, Hans.
I: Science Translational Medicine, Bind 12, Nr. 569, eaax9929, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma
AU - Stokholm, Jakob
AU - Thorsen, Jonathan
AU - Blaser, Martin J
AU - Rasmussen, Morten A.
AU - Hjelmsø, Mathis
AU - Shah, Shiraz
AU - Christensen, Emil D.
AU - Chawes, Bo L.
AU - Bønnelykke, Klaus
AU - Brix, Susanne
AU - Mortensen, Martin S.
AU - Brejnrod, Asker
AU - Vestergaard, Gisle
AU - Trivedi, Urvish
AU - Sørensen, Søren J.
AU - Bisgaard, Hans
N1 - Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
PY - 2020
Y1 - 2020
N2 - There have been reports of associations between cesarean section delivery and the risk of childhood asthma, potentially mediated through changes in the gut microbiota. We followed 700 children in the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) cohort prospectively from birth. We examined the effects of cesarean section delivery on gut microbial composition by 16S rRNA gene amplicon sequencing during the first year of life. We then explored whether gut microbial perturbations due to delivery mode were associated with a risk of developing asthma in the first 6 years of life. Delivery by cesarean section was accompanied by marked changes in gut microbiota composition at one week and one month of age, but by one year of age only minor differences persisted compared to vaginal delivery. Increased asthma risk was found in children born by cesarean section only if their gut microbiota composition at 1 year of age still retained a cesarean section microbial signature, suggesting that appropriate maturation of the gut microbiota could mitigate against the increased asthma risk associated with gut microbial changes due to cesarean section delivery.
AB - There have been reports of associations between cesarean section delivery and the risk of childhood asthma, potentially mediated through changes in the gut microbiota. We followed 700 children in the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) cohort prospectively from birth. We examined the effects of cesarean section delivery on gut microbial composition by 16S rRNA gene amplicon sequencing during the first year of life. We then explored whether gut microbial perturbations due to delivery mode were associated with a risk of developing asthma in the first 6 years of life. Delivery by cesarean section was accompanied by marked changes in gut microbiota composition at one week and one month of age, but by one year of age only minor differences persisted compared to vaginal delivery. Increased asthma risk was found in children born by cesarean section only if their gut microbiota composition at 1 year of age still retained a cesarean section microbial signature, suggesting that appropriate maturation of the gut microbiota could mitigate against the increased asthma risk associated with gut microbial changes due to cesarean section delivery.
U2 - 10.1126/scitranslmed.aax9929
DO - 10.1126/scitranslmed.aax9929
M3 - Journal article
C2 - 33177184
VL - 12
JO - Science Translational Medicine
JF - Science Translational Medicine
SN - 1946-6234
IS - 569
M1 - eaax9929
ER -
ID: 251413972