Defining the Design Principles of Skin Epidermis Postnatal Growth

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Standard

Defining the Design Principles of Skin Epidermis Postnatal Growth. / Dekoninck, Sophie; Hannezo, Edouard; Sifrim, Alejandro; Miroshnikova, Yekaterina A; Aragona, Mariaceleste; Malfait, Milan; Gargouri, Souhir; de Neunheuser, Charlotte; Dubois, Christine; Voet, Thierry; Wickström, Sara A; Simons, Benjamin D; Blanpain, Cédric.

I: Cell, Bind 181, Nr. 3, 30.04.2020, s. 604-620.e22.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Dekoninck, S, Hannezo, E, Sifrim, A, Miroshnikova, YA, Aragona, M, Malfait, M, Gargouri, S, de Neunheuser, C, Dubois, C, Voet, T, Wickström, SA, Simons, BD & Blanpain, C 2020, 'Defining the Design Principles of Skin Epidermis Postnatal Growth', Cell, bind 181, nr. 3, s. 604-620.e22. https://doi.org/10.1016/j.cell.2020.03.015

APA

Dekoninck, S., Hannezo, E., Sifrim, A., Miroshnikova, Y. A., Aragona, M., Malfait, M., Gargouri, S., de Neunheuser, C., Dubois, C., Voet, T., Wickström, S. A., Simons, B. D., & Blanpain, C. (2020). Defining the Design Principles of Skin Epidermis Postnatal Growth. Cell, 181(3), 604-620.e22. https://doi.org/10.1016/j.cell.2020.03.015

Vancouver

Dekoninck S, Hannezo E, Sifrim A, Miroshnikova YA, Aragona M, Malfait M o.a. Defining the Design Principles of Skin Epidermis Postnatal Growth. Cell. 2020 apr. 30;181(3):604-620.e22. https://doi.org/10.1016/j.cell.2020.03.015

Author

Dekoninck, Sophie ; Hannezo, Edouard ; Sifrim, Alejandro ; Miroshnikova, Yekaterina A ; Aragona, Mariaceleste ; Malfait, Milan ; Gargouri, Souhir ; de Neunheuser, Charlotte ; Dubois, Christine ; Voet, Thierry ; Wickström, Sara A ; Simons, Benjamin D ; Blanpain, Cédric. / Defining the Design Principles of Skin Epidermis Postnatal Growth. I: Cell. 2020 ; Bind 181, Nr. 3. s. 604-620.e22.

Bibtex

@article{e9dc874e07e1410087581bb480029ebb,

title = "Defining the Design Principles of Skin Epidermis Postnatal Growth",

abstract = "During embryonic and postnatal development, organs and tissues grow steadily to achieve their final size at the end of puberty. However, little is known about the cellular dynamics that mediate postnatal growth. By combining in vivo clonal lineage tracing, proliferation kinetics, single-cell transcriptomics, and in vitro micro-pattern experiments, we resolved the cellular dynamics taking place during postnatal skin epidermis expansion. Our data revealed that harmonious growth is engineered by a single population of developmental progenitors presenting a fixed fate imbalance of self-renewing divisions with an ever-decreasing proliferation rate. Single-cell RNA sequencing revealed that epidermal developmental progenitors form a more uniform population compared with adult stem and progenitor cells. Finally, we found that the spatial pattern of cell division orientation is dictated locally by the underlying collagen fiber orientation. Our results uncover a simple design principle of organ growth where progenitors and differentiated cells expand in harmony with their surrounding tissues.",

keywords = "Animals, Animals, Outbred Strains, Cell Differentiation/physiology, Cell Division/physiology, Cell Lineage/genetics, Cell Proliferation/physiology, Cells, Cultured, Epidermal Cells/metabolism, Epidermis/growth & development, Female, Male, Mice, Mice, Transgenic, Skin/growth & development, Stem Cells/cytology",

author = "Sophie Dekoninck and Edouard Hannezo and Alejandro Sifrim and Miroshnikova, {Yekaterina A} and Mariaceleste Aragona and Milan Malfait and Souhir Gargouri and {de Neunheuser}, Charlotte and Christine Dubois and Thierry Voet and Wickstr{\"o}m, {Sara A} and Simons, {Benjamin D} and C{\'e}dric Blanpain",

year = "2020",

month = apr,

day = "30",

doi = "10.1016/j.cell.2020.03.015",

language = "English",

volume = "181",

pages = "604--620.e22",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "3",

}

RIS

TY - JOUR

T1 - Defining the Design Principles of Skin Epidermis Postnatal Growth

AU - Dekoninck, Sophie

AU - Hannezo, Edouard

AU - Sifrim, Alejandro

AU - Miroshnikova, Yekaterina A

AU - Aragona, Mariaceleste

AU - Malfait, Milan

AU - Gargouri, Souhir

AU - de Neunheuser, Charlotte

AU - Dubois, Christine

AU - Voet, Thierry

AU - Wickström, Sara A

AU - Simons, Benjamin D

AU - Blanpain, Cédric

PY - 2020/4/30

Y1 - 2020/4/30

N2 - During embryonic and postnatal development, organs and tissues grow steadily to achieve their final size at the end of puberty. However, little is known about the cellular dynamics that mediate postnatal growth. By combining in vivo clonal lineage tracing, proliferation kinetics, single-cell transcriptomics, and in vitro micro-pattern experiments, we resolved the cellular dynamics taking place during postnatal skin epidermis expansion. Our data revealed that harmonious growth is engineered by a single population of developmental progenitors presenting a fixed fate imbalance of self-renewing divisions with an ever-decreasing proliferation rate. Single-cell RNA sequencing revealed that epidermal developmental progenitors form a more uniform population compared with adult stem and progenitor cells. Finally, we found that the spatial pattern of cell division orientation is dictated locally by the underlying collagen fiber orientation. Our results uncover a simple design principle of organ growth where progenitors and differentiated cells expand in harmony with their surrounding tissues.

AB - During embryonic and postnatal development, organs and tissues grow steadily to achieve their final size at the end of puberty. However, little is known about the cellular dynamics that mediate postnatal growth. By combining in vivo clonal lineage tracing, proliferation kinetics, single-cell transcriptomics, and in vitro micro-pattern experiments, we resolved the cellular dynamics taking place during postnatal skin epidermis expansion. Our data revealed that harmonious growth is engineered by a single population of developmental progenitors presenting a fixed fate imbalance of self-renewing divisions with an ever-decreasing proliferation rate. Single-cell RNA sequencing revealed that epidermal developmental progenitors form a more uniform population compared with adult stem and progenitor cells. Finally, we found that the spatial pattern of cell division orientation is dictated locally by the underlying collagen fiber orientation. Our results uncover a simple design principle of organ growth where progenitors and differentiated cells expand in harmony with their surrounding tissues.

KW - Animals

KW - Animals, Outbred Strains

KW - Cell Differentiation/physiology

KW - Cell Division/physiology

KW - Cell Lineage/genetics

KW - Cell Proliferation/physiology

KW - Cells, Cultured

KW - Epidermal Cells/metabolism

KW - Epidermis/growth & development

KW - Female

KW - Male

KW - Mice

KW - Mice, Transgenic

KW - Skin/growth & development

KW - Stem Cells/cytology

U2 - 10.1016/j.cell.2020.03.015

DO - 10.1016/j.cell.2020.03.015

M3 - Journal article

C2 - 32259486

VL - 181

SP - 604-620.e22

JO - Cell

JF - Cell

SN - 0092-8674

IS - 3

ER -

ID: 259565999