Defining the clinical course of multiple sclerosis: The 2013 revisions
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Defining the clinical course of multiple sclerosis : The 2013 revisions. / Lublin, Fred D; Reingold, Stephen C; Cohen, Jeffrey A; Cutter, Gary R; Sørensen, Per Soelberg; Thompson, Alan J; Wolinsky, Jerry S; Balcer, Laura J; Banwell, Brenda; Barkhof, Frederik; Bebo, Bruce; Calabresi, Peter A; Clanet, Michel; Comi, Giancarlo; Fox, Robert J; Freedman, Mark S; Goodman, Andrew D; Inglese, Matilde; Kappos, Ludwig; Kieseier, Bernd C; Lincoln, John A; Lubetzki, Catherine; Miller, Aaron E; Montalban, Xavier; O'Connor, Paul W; Petkau, John; Pozzilli, Carlo; Rudick, Richard A; Sormani, Maria Pia; Stüve, Olaf; Waubant, Emmanuelle; Polman, Chris H.
I: Neurology, Bind 83, Nr. 3, 07.2014, s. 278-286.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Defining the clinical course of multiple sclerosis
T2 - The 2013 revisions
AU - Lublin, Fred D
AU - Reingold, Stephen C
AU - Cohen, Jeffrey A
AU - Cutter, Gary R
AU - Sørensen, Per Soelberg
AU - Thompson, Alan J
AU - Wolinsky, Jerry S
AU - Balcer, Laura J
AU - Banwell, Brenda
AU - Barkhof, Frederik
AU - Bebo, Bruce
AU - Calabresi, Peter A
AU - Clanet, Michel
AU - Comi, Giancarlo
AU - Fox, Robert J
AU - Freedman, Mark S
AU - Goodman, Andrew D
AU - Inglese, Matilde
AU - Kappos, Ludwig
AU - Kieseier, Bernd C
AU - Lincoln, John A
AU - Lubetzki, Catherine
AU - Miller, Aaron E
AU - Montalban, Xavier
AU - O'Connor, Paul W
AU - Petkau, John
AU - Pozzilli, Carlo
AU - Rudick, Richard A
AU - Sormani, Maria Pia
AU - Stüve, Olaf
AU - Waubant, Emmanuelle
AU - Polman, Chris H
N1 - © 2014 American Academy of Neurology.
PY - 2014/7
Y1 - 2014/7
N2 - Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment of clinical trials, and treatment decision-making. Standardized descriptions published in 1996 based on a survey of international MS experts provided purely clinical phenotypes based on data and consensus at that time, but imaging and biological correlates were lacking. Increased understanding of MS and its pathology, coupled with general concern that the original descriptors may not adequately reflect more recently identified clinical aspects of the disease, prompted a re-examination of MS disease phenotypes by the International Advisory Committee on Clinical Trials of MS. While imaging and biological markers that might provide objective criteria for separating clinical phenotypes are lacking, we propose refined descriptors that include consideration of disease activity (based on clinical relapse rate and imaging findings) and disease progression. Strategies for future research to better define phenotypes are also outlined.
AB - Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment of clinical trials, and treatment decision-making. Standardized descriptions published in 1996 based on a survey of international MS experts provided purely clinical phenotypes based on data and consensus at that time, but imaging and biological correlates were lacking. Increased understanding of MS and its pathology, coupled with general concern that the original descriptors may not adequately reflect more recently identified clinical aspects of the disease, prompted a re-examination of MS disease phenotypes by the International Advisory Committee on Clinical Trials of MS. While imaging and biological markers that might provide objective criteria for separating clinical phenotypes are lacking, we propose refined descriptors that include consideration of disease activity (based on clinical relapse rate and imaging findings) and disease progression. Strategies for future research to better define phenotypes are also outlined.
KW - Clinical Trials as Topic
KW - Consensus
KW - Humans
KW - Multiple Sclerosis
KW - Societies, Medical
U2 - 10.1212/WNL.0000000000000560
DO - 10.1212/WNL.0000000000000560
M3 - Review
C2 - 24871874
VL - 83
SP - 278
EP - 286
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 3
ER -
ID: 138376276