Deeper insight into the drug release mechanisms in Eudragit RL-based delivery systems
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Deeper insight into the drug release mechanisms in Eudragit RL-based delivery systems. / Glaessl, B.; Siepmann, F.; Tucker, I.; Rades, T.; Siepmann, J.
I: International Journal of Pharmaceutics, Bind 389, Nr. 1-2, 15.04.2010, s. 139-146.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Deeper insight into the drug release mechanisms in Eudragit RL-based delivery systems
AU - Glaessl, B.
AU - Siepmann, F.
AU - Tucker, I.
AU - Rades, T.
AU - Siepmann, J.
N1 - Funding Information: The authors are grateful for the support of this work by the “Nord-Pas de Calais” Regional Council (Interdisciplinary Research Centre on Drug Products, PRIM: “Pôle de Recherche Interdisciplinaire pour le Médicament”).
PY - 2010/4/15
Y1 - 2010/4/15
N2 - Tartaric acid, metoprolol free base and metoprolol tartrate act as plasticisers for Eudragit RL, in the dry but also in the wet state. Fitting analytical solutions of Fick's second law of diffusion allowed for the determination of the apparent diffusivities of water and of tartaric acid, metoprolol free base and metoprolol tartrate upon exposure of thin films to 0.1 M HCl, phosphate buffer pH 7.4 and distilled water. Based on these calculations, it could be shown that water penetration into the systems is predominantly controlled by pure diffusion, irrespective of the type of bulk fluid. Interestingly, the plasticising effect of metoprolol tartrate was much more pronounced than that of tartaric acid, resulting in monotonically increasing diffusion coefficients with increasing initial drug content. In contrast, the plasticising activity of metoprolol free base was very limited in the wet state, due to drug precipitation in aqueous environments. Partially observed film shrinking (after an initial system swelling) could be attributed to the leaching of the plasticising compound into the release medium, resulting in less flexible polymeric networks and squeezing out of water. Also the release of tartaric acid, metoprolol free base and metoprolol tartrate into the investigated bulk fluids was predominantly diffusion controlled. However, the precipitation of the free base in wet films rendered the mass transport mechanisms more complex, at moderate and high initial drug loadings. The obtained new insight into the underlying drug release mechanisms in Eudragit RL networks can help to facilitate the optimisation of this type of dosage forms.
AB - Tartaric acid, metoprolol free base and metoprolol tartrate act as plasticisers for Eudragit RL, in the dry but also in the wet state. Fitting analytical solutions of Fick's second law of diffusion allowed for the determination of the apparent diffusivities of water and of tartaric acid, metoprolol free base and metoprolol tartrate upon exposure of thin films to 0.1 M HCl, phosphate buffer pH 7.4 and distilled water. Based on these calculations, it could be shown that water penetration into the systems is predominantly controlled by pure diffusion, irrespective of the type of bulk fluid. Interestingly, the plasticising effect of metoprolol tartrate was much more pronounced than that of tartaric acid, resulting in monotonically increasing diffusion coefficients with increasing initial drug content. In contrast, the plasticising activity of metoprolol free base was very limited in the wet state, due to drug precipitation in aqueous environments. Partially observed film shrinking (after an initial system swelling) could be attributed to the leaching of the plasticising compound into the release medium, resulting in less flexible polymeric networks and squeezing out of water. Also the release of tartaric acid, metoprolol free base and metoprolol tartrate into the investigated bulk fluids was predominantly diffusion controlled. However, the precipitation of the free base in wet films rendered the mass transport mechanisms more complex, at moderate and high initial drug loadings. The obtained new insight into the underlying drug release mechanisms in Eudragit RL networks can help to facilitate the optimisation of this type of dosage forms.
KW - Diffusion
KW - Drug polymer interaction
KW - Eudragit
KW - Modelling
KW - Release mechanism
UR - http://www.scopus.com/inward/record.url?scp=77349087995&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2010.01.031
DO - 10.1016/j.ijpharm.2010.01.031
M3 - Journal article
C2 - 20105459
AN - SCOPUS:77349087995
VL - 389
SP - 139
EP - 146
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-2
ER -
ID: 299416886