Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia
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Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia. / Rasmussen, Hans; Erritzoe, David; Andersen, Rune; Ebdrup, Bjorn H; Aggernaes, Bodil; Oranje, Bob; Kalbitzer, Jan; Madsen, Jacob; Pinborg, Lars Hageman; Baaré, William; Svarer, Claus; Lublin, Henrik; Knudsen, Gitte M; Glenthøj, Birte Yding.
I: Archives of General Psychiatry, Bind 67, Nr. 1, 01.01.2010, s. 9-16.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia
AU - Rasmussen, Hans
AU - Erritzoe, David
AU - Andersen, Rune
AU - Ebdrup, Bjorn H
AU - Aggernaes, Bodil
AU - Oranje, Bob
AU - Kalbitzer, Jan
AU - Madsen, Jacob
AU - Pinborg, Lars Hageman
AU - Baaré, William
AU - Svarer, Claus
AU - Lublin, Henrik
AU - Knudsen, Gitte M
AU - Glenthøj, Birte Yding
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Postmortem investigations and the receptor affinity profile of atypical antipsychotics have implicated the participation of serotonin(2A) receptors in the pathophysiology of schizophrenia. Most postmortem studies point toward lower cortical serotonin(2A) binding in schizophrenic patients. However, in vivo studies of serotonin(2A) binding report conflicting results, presumably because sample sizes have been small or because schizophrenic patients who were not antipsychotic-naive were included. Furthermore, the relationships between serotonin(2A) binding, psychopathology, and central neurocognitive deficits in schizophrenia are unclear.
AB - Postmortem investigations and the receptor affinity profile of atypical antipsychotics have implicated the participation of serotonin(2A) receptors in the pathophysiology of schizophrenia. Most postmortem studies point toward lower cortical serotonin(2A) binding in schizophrenic patients. However, in vivo studies of serotonin(2A) binding report conflicting results, presumably because sample sizes have been small or because schizophrenic patients who were not antipsychotic-naive were included. Furthermore, the relationships between serotonin(2A) binding, psychopathology, and central neurocognitive deficits in schizophrenia are unclear.
U2 - http://dx.doi.org/10.1001/archgenpsychiatry.2009.176
DO - http://dx.doi.org/10.1001/archgenpsychiatry.2009.176
M3 - Journal article
VL - 67
SP - 9
EP - 16
JO - JAMA Psychiatry
JF - JAMA Psychiatry
SN - 2168-622X
IS - 1
ER -
ID: 34046099