TY - JOUR

T1 - Debate

T2 - differences and similarities between tension-type headache and migraine

AU - Onan, Dilara

AU - Younis, Samaira

AU - Wellsgatnik, William David

AU - Farham, Fatemeh

AU - Andruškevičius, Saulius

AU - Abashidze, Ana

AU - Jusupova, Asel

AU - Romanenko, Yuriy

AU - Grosu, Oxana

AU - Moldokulova, Meerimgul Zamirbekovna

AU - Mursalova, Ulkar

AU - Saidkhodjaeva, Saida

AU - Martelletti, Paolo

AU - Ashina, Sait

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2023

Y1 - 2023

N2 - Tension-type headache (TTH) and migraine are two common primary headaches distinguished by clinical characteristics according to the 3rd edition of the International Classification of Headache Disorders. Migraine is identified by specific features such as being more prevalent in females, being aggravated by physical activity, certain genetic factors, having photophobia, phonophobia, nausea, vomiting, or aura, and responding to specific drugs. Nonetheless, TTH and migraine share some common characteristics, such as onset occurring in the 20 s, and being triggered by psychological factors like stress, moderate pain severity, and mild nausea in chronic TTH. Both conditions involve the trigeminovascular system in their pathophysiology. However, distinguishing between TTH and migraine in clinical practice, research, and epidemiological studies can be challenging, as there is a lack of specific diagnostic tests and biomarkers. Moreover, both conditions may coexist, further complicating the diagnostic process. This review aims to explore the similarities and differences in the pathophysiology, epidemiology, burden and disability, comorbidities, and responses to pharmacological and non-pharmacological treatments of TTH and migraine. The review also discusses future research directions to address the diagnostic challenges and improve the understanding and management of these conditions. Graphical Abstract: [Figure not available: see fulltext.]

AB - Tension-type headache (TTH) and migraine are two common primary headaches distinguished by clinical characteristics according to the 3rd edition of the International Classification of Headache Disorders. Migraine is identified by specific features such as being more prevalent in females, being aggravated by physical activity, certain genetic factors, having photophobia, phonophobia, nausea, vomiting, or aura, and responding to specific drugs. Nonetheless, TTH and migraine share some common characteristics, such as onset occurring in the 20 s, and being triggered by psychological factors like stress, moderate pain severity, and mild nausea in chronic TTH. Both conditions involve the trigeminovascular system in their pathophysiology. However, distinguishing between TTH and migraine in clinical practice, research, and epidemiological studies can be challenging, as there is a lack of specific diagnostic tests and biomarkers. Moreover, both conditions may coexist, further complicating the diagnostic process. This review aims to explore the similarities and differences in the pathophysiology, epidemiology, burden and disability, comorbidities, and responses to pharmacological and non-pharmacological treatments of TTH and migraine. The review also discusses future research directions to address the diagnostic challenges and improve the understanding and management of these conditions. Graphical Abstract: [Figure not available: see fulltext.]

KW - Central sensitization

KW - CGRP

KW - Headache

KW - International Classification of Headache Disorders

KW - Migraine

KW - Pericranial tenderness

KW - Tension-type headache

KW - Triptan

U2 - 10.1186/s10194-023-01614-0

DO - 10.1186/s10194-023-01614-0

M3 - Review

C2 - 37474899

AN - SCOPUS:85165342489

VL - 24

JO - Journal of Headache and Pain

JF - Journal of Headache and Pain

SN - 1129-2369

M1 - 92

ER -