DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder
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DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder. / Håvik, Bjarte; Degenhardt, Franziska A; Johansson, Stefan; Fernandes, Carla P D; Hinney, Anke; Scherag, André; Lybæk, Helle; Djurovic, Srdjan; Christoforou, Andrea; Ersland, Kari M; Giddaluru, Sudheer; O'Donovan, Michael C; Owen, Michael J; Craddock, Nick; Mühleisen, Thomas W; Mattheisen, Manuel; Schimmelmann, Benno G; Renner, Tobias; Warnke, Andreas; Herpertz-Dahlmann, Beate; Sinzig, Judith; Albayrak, Özgür; Rietschel, Marcella; Nöthen, Markus M; Bramham, Clive R; Werge, Thomas; Hebebrand, Johannes; Haavik, Jan; Andreassen, Ole A; Cichon, Sven; Steen, Vidar M; Le Hellard, Stéphanie.
I: P L o S One, Bind 7, Nr. 4, 2012, s. e35424.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder
AU - Håvik, Bjarte
AU - Degenhardt, Franziska A
AU - Johansson, Stefan
AU - Fernandes, Carla P D
AU - Hinney, Anke
AU - Scherag, André
AU - Lybæk, Helle
AU - Djurovic, Srdjan
AU - Christoforou, Andrea
AU - Ersland, Kari M
AU - Giddaluru, Sudheer
AU - O'Donovan, Michael C
AU - Owen, Michael J
AU - Craddock, Nick
AU - Mühleisen, Thomas W
AU - Mattheisen, Manuel
AU - Schimmelmann, Benno G
AU - Renner, Tobias
AU - Warnke, Andreas
AU - Herpertz-Dahlmann, Beate
AU - Sinzig, Judith
AU - Albayrak, Özgür
AU - Rietschel, Marcella
AU - Nöthen, Markus M
AU - Bramham, Clive R
AU - Werge, Thomas
AU - Hebebrand, Johannes
AU - Haavik, Jan
AU - Andreassen, Ole A
AU - Cichon, Sven
AU - Steen, Vidar M
AU - Le Hellard, Stéphanie
PY - 2012
Y1 - 2012
N2 - Doublecortin and calmodulin like kinase 1 (DCLK1) is implicated in synaptic plasticity and neurodevelopment. Genetic variants in DCLK1 are associated with cognitive traits, specifically verbal memory and general cognition. We investigated the role of DCLK1 variants in three psychiatric disorders that have neuro-cognitive dysfunctions: schizophrenia (SCZ), bipolar affective disorder (BP) and attention deficit/hyperactivity disorder (ADHD). We mined six genome wide association studies (GWASs) that were available publically or through collaboration; three for BP, two for SCZ and one for ADHD. We also genotyped the DCLK1 region in additional samples of cases with SCZ, BP or ADHD and controls that had not been whole-genome typed. In total, 9895 subjects were analysed, including 5308 normal controls and 4,587 patients (1,125 with SCZ, 2,496 with BP and 966 with ADHD). Several DCLK1 variants were associated with disease phenotypes in the different samples. The main effect was observed for rs7989807 in intron 3, which was strongly associated with SCZ alone and even more so when cases with SCZ and ADHD were combined (P-value = 4 × 10(-5) and 4 × 10(-6), respectively). Associations were also observed with additional markers in intron 3 (combination of SCZ, ADHD and BP), intron 19 (SCZ+BP) and the 3'UTR (SCZ+BP). Our results suggest that genetic variants in DCLK1 are associated with SCZ and, to a lesser extent, with ADHD and BP. Interestingly the association is strongest when SCZ and ADHD are considered together, suggesting common genetic susceptibility. Given that DCLK1 variants were previously found to be associated with cognitive traits, these results are consistent with the role of DCLK1 in neurodevelopment and synaptic plasticity.
AB - Doublecortin and calmodulin like kinase 1 (DCLK1) is implicated in synaptic plasticity and neurodevelopment. Genetic variants in DCLK1 are associated with cognitive traits, specifically verbal memory and general cognition. We investigated the role of DCLK1 variants in three psychiatric disorders that have neuro-cognitive dysfunctions: schizophrenia (SCZ), bipolar affective disorder (BP) and attention deficit/hyperactivity disorder (ADHD). We mined six genome wide association studies (GWASs) that were available publically or through collaboration; three for BP, two for SCZ and one for ADHD. We also genotyped the DCLK1 region in additional samples of cases with SCZ, BP or ADHD and controls that had not been whole-genome typed. In total, 9895 subjects were analysed, including 5308 normal controls and 4,587 patients (1,125 with SCZ, 2,496 with BP and 966 with ADHD). Several DCLK1 variants were associated with disease phenotypes in the different samples. The main effect was observed for rs7989807 in intron 3, which was strongly associated with SCZ alone and even more so when cases with SCZ and ADHD were combined (P-value = 4 × 10(-5) and 4 × 10(-6), respectively). Associations were also observed with additional markers in intron 3 (combination of SCZ, ADHD and BP), intron 19 (SCZ+BP) and the 3'UTR (SCZ+BP). Our results suggest that genetic variants in DCLK1 are associated with SCZ and, to a lesser extent, with ADHD and BP. Interestingly the association is strongest when SCZ and ADHD are considered together, suggesting common genetic susceptibility. Given that DCLK1 variants were previously found to be associated with cognitive traits, these results are consistent with the role of DCLK1 in neurodevelopment and synaptic plasticity.
U2 - 10.1371/journal.pone.0035424
DO - 10.1371/journal.pone.0035424
M3 - Journal article
C2 - 22539971
VL - 7
SP - e35424
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 4
ER -
ID: 48611245