Days alive and out of hospital following primary surgery for oral cavity squamous cell carcinoma
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Days alive and out of hospital following primary surgery for oral cavity squamous cell carcinoma. / Awada, Hussein Nasser; Larsen, Mikkel Holm; Kjær, Eva Kristine Ruud; Jensen, Jakob Schmidt; Jakobsen, Kathrine Kronberg; Scott, Susanne; Wessel, Irene; Kehlet, Henrik; Grønhøj, Christian; von Buchwald, Christian.
I: Acta Oncologica, Bind 61, Nr. 12, 2022, s. 1463-1472.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Days alive and out of hospital following primary surgery for oral cavity squamous cell carcinoma
AU - Awada, Hussein Nasser
AU - Larsen, Mikkel Holm
AU - Kjær, Eva Kristine Ruud
AU - Jensen, Jakob Schmidt
AU - Jakobsen, Kathrine Kronberg
AU - Scott, Susanne
AU - Wessel, Irene
AU - Kehlet, Henrik
AU - Grønhøj, Christian
AU - von Buchwald, Christian
N1 - Publisher Copyright: © 2022 Acta Oncologica Foundation.
PY - 2022
Y1 - 2022
N2 - Background: Days Alive and Out of Hospital (DAOH) is a recently introduced, readily obtainable postoperative outcome measure method that expresses procedure and disease-associated morbidity and mortality. In this study, we evaluated DAOH with 30- and 365-days follow-up periods after primary surgery (DAOH30 and DAOH365, respectively) for patients with oral cavity squamous cell carcinoma (OSCC). The aim of this study is to identify patient-, procedure- and disease-associated risk factors for patients treated with primary surgery for primary OSCC. Material and methods: This retrospective cohort study from a prospective collected database represents patients from Eastern Denmark surgically treated for primary OSCC in the period 2000–2014. DAOH30 and DAOH365 were calculated and associations with patient characteristics including comorbidity, tumor characteristics, clinical outcomes such as length of stay, readmission, and mortality were evaluated. Tests for difference and significance between groups were assessed with Mann–Whitney U test and quantile linear regression. Results: We included 867 patients (63% males, median age: 63 years (IQR 56–70 years)). Median DAOH30 and DAOH365 after OSCC surgery were 25 days (IQR 21–27 days) and 356 days (IQR 336–360 days), respectively. Alcohol consumption had a significant association with a lower DAOH365, p < 0.01, but not with DAOH30. Advanced T-stage, adjuvant radiotherapy (RT) and increased Charlson Comorbidity Index (CCI) score was significantly associated with a lower DAOH30 and DAOH365. Conclusion: In this population-based study in OSCC patients treated with primary surgery, we found that DAOH after 30 days was 25 days (83%), while DAOH after 365 days was 356 days (98%). Advanced T-stage acts as a predictor for significant DAOH30 and DAOH365 reduction while excessive alcohol consumption predicts a significant DAOH365 reduction. Readmission within 30 days following surgery was associated with further readmission within one year.
AB - Background: Days Alive and Out of Hospital (DAOH) is a recently introduced, readily obtainable postoperative outcome measure method that expresses procedure and disease-associated morbidity and mortality. In this study, we evaluated DAOH with 30- and 365-days follow-up periods after primary surgery (DAOH30 and DAOH365, respectively) for patients with oral cavity squamous cell carcinoma (OSCC). The aim of this study is to identify patient-, procedure- and disease-associated risk factors for patients treated with primary surgery for primary OSCC. Material and methods: This retrospective cohort study from a prospective collected database represents patients from Eastern Denmark surgically treated for primary OSCC in the period 2000–2014. DAOH30 and DAOH365 were calculated and associations with patient characteristics including comorbidity, tumor characteristics, clinical outcomes such as length of stay, readmission, and mortality were evaluated. Tests for difference and significance between groups were assessed with Mann–Whitney U test and quantile linear regression. Results: We included 867 patients (63% males, median age: 63 years (IQR 56–70 years)). Median DAOH30 and DAOH365 after OSCC surgery were 25 days (IQR 21–27 days) and 356 days (IQR 336–360 days), respectively. Alcohol consumption had a significant association with a lower DAOH365, p < 0.01, but not with DAOH30. Advanced T-stage, adjuvant radiotherapy (RT) and increased Charlson Comorbidity Index (CCI) score was significantly associated with a lower DAOH30 and DAOH365. Conclusion: In this population-based study in OSCC patients treated with primary surgery, we found that DAOH after 30 days was 25 days (83%), while DAOH after 365 days was 356 days (98%). Advanced T-stage acts as a predictor for significant DAOH30 and DAOH365 reduction while excessive alcohol consumption predicts a significant DAOH365 reduction. Readmission within 30 days following surgery was associated with further readmission within one year.
KW - enhanced recovery after surgery
KW - head and neck surgery
KW - postoperative complication
KW - Postoperative outcome
U2 - 10.1080/0284186X.2022.2156810
DO - 10.1080/0284186X.2022.2156810
M3 - Journal article
C2 - 36527436
AN - SCOPUS:85144171961
VL - 61
SP - 1463
EP - 1472
JO - Acta Oncologica
JF - Acta Oncologica
SN - 1100-1704
IS - 12
ER -
ID: 341063239