Cystic fibrosis in Denmark 1945 to 1985. An analysis of incidence, mortality and influence of centralized treatment on survival
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Cystic fibrosis in Denmark 1945 to 1985. An analysis of incidence, mortality and influence of centralized treatment on survival. / Nielsen, O H; Thomsen, B L; Green, A; Andersen, P K; Hauge, M; Schiøtz, P O.
I: Acta Paediatrica Scandinavica, Bind 77, Nr. 6, 11.1988, s. 836-41.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Cystic fibrosis in Denmark 1945 to 1985. An analysis of incidence, mortality and influence of centralized treatment on survival
AU - Nielsen, O H
AU - Thomsen, B L
AU - Green, A
AU - Andersen, P K
AU - Hauge, M
AU - Schiøtz, P O
PY - 1988/11
Y1 - 1988/11
N2 - The entire population of cystic fibrosis (CF) patients in Denmark diagnosed in the period January 1, 1945, to June 30, 1985, comprised 514 persons of whom 62 were diagnosed at autopsy. Of the remaining 452 patients, 372 were probands and 80 were secondary cases. The effect of a centralized treatment on the prognosis was evaluated using a Cox's regression model. Furthermore an incidence analysis was performed using probands including autopsies. Centralized treatment had a significantly beneficial effect on the prognosis (p = 0.02), the death intensity (hazard rate) being decreased by a factor of 0.60. It was calculated that at present 1 out of 4,760 newborn Danes may be diagnosed as suffering from CF before the age of 15 years, and 3% of the Danish population are heterozygotes for CF.
AB - The entire population of cystic fibrosis (CF) patients in Denmark diagnosed in the period January 1, 1945, to June 30, 1985, comprised 514 persons of whom 62 were diagnosed at autopsy. Of the remaining 452 patients, 372 were probands and 80 were secondary cases. The effect of a centralized treatment on the prognosis was evaluated using a Cox's regression model. Furthermore an incidence analysis was performed using probands including autopsies. Centralized treatment had a significantly beneficial effect on the prognosis (p = 0.02), the death intensity (hazard rate) being decreased by a factor of 0.60. It was calculated that at present 1 out of 4,760 newborn Danes may be diagnosed as suffering from CF before the age of 15 years, and 3% of the Danish population are heterozygotes for CF.
KW - Adolescent
KW - Adult
KW - Anti-Bacterial Agents/therapeutic use
KW - Child
KW - Child, Preschool
KW - Cohort Studies
KW - Cystic Fibrosis/drug therapy
KW - Denmark
KW - Female
KW - Forced Expiratory Volume
KW - Humans
KW - Infant
KW - Male
KW - Prognosis
M3 - Journal article
C2 - 3264656
VL - 77
SP - 836
EP - 841
JO - Acta Paediatrica Scandinavica
JF - Acta Paediatrica Scandinavica
SN - 0001-656X
IS - 6
ER -
ID: 218726457