Cyclebase.org--a comprehensive multi-organism online database of cell-cycle experiments
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Cyclebase.org--a comprehensive multi-organism online database of cell-cycle experiments. / Gauthier, Nicholas Paul; Larsen, Malene Erup; Wernersson, Rasmus; de Lichtenberg, Ulrik; Jensen, Lars Juhl; Brunak, Søren; Jensen, Thomas Skøt.
I: Nucleic Acids Research, Bind 36, Nr. Database issue, 2008, s. D854-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cyclebase.org--a comprehensive multi-organism online database of cell-cycle experiments
AU - Gauthier, Nicholas Paul
AU - Larsen, Malene Erup
AU - Wernersson, Rasmus
AU - de Lichtenberg, Ulrik
AU - Jensen, Lars Juhl
AU - Brunak, Søren
AU - Jensen, Thomas Skøt
PY - 2008
Y1 - 2008
N2 - The past decade has seen the publication of a large number of cell-cycle microarray studies and many more are in the pipeline. However, data from these experiments are not easy to access, combine and evaluate. We have developed a centralized database with an easy-to-use interface, Cyclebase.org, for viewing and downloading these data. The user interface facilitates searches for genes of interest as well as downloads of genome-wide results. Individual genes are displayed with graphs of expression profiles throughout the cell cycle from all available experiments. These expression profiles are normalized to a common timescale to enable inspection of the combined experimental evidence. Furthermore, state-of-the-art computational analyses provide key information on both individual experiments and combined datasets such as whether or not a gene is periodically expressed and, if so, the time of peak expression. Cyclebase is available at http://www.cyclebase.org.
AB - The past decade has seen the publication of a large number of cell-cycle microarray studies and many more are in the pipeline. However, data from these experiments are not easy to access, combine and evaluate. We have developed a centralized database with an easy-to-use interface, Cyclebase.org, for viewing and downloading these data. The user interface facilitates searches for genes of interest as well as downloads of genome-wide results. Individual genes are displayed with graphs of expression profiles throughout the cell cycle from all available experiments. These expression profiles are normalized to a common timescale to enable inspection of the combined experimental evidence. Furthermore, state-of-the-art computational analyses provide key information on both individual experiments and combined datasets such as whether or not a gene is periodically expressed and, if so, the time of peak expression. Cyclebase is available at http://www.cyclebase.org.
U2 - 10.1093/nar/gkm729
DO - 10.1093/nar/gkm729
M3 - Journal article
C2 - 17940094
VL - 36
SP - D854-9
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - Database issue
ER -
ID: 40740282