Curvature strains as a global orchestrator of morphogenesis
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Dokumenter
- PhysRevResearch.4.023171
Forlagets udgivne version, 6,42 MB, PDF-dokument
Successful morphogenesis on the scale of organs or organisms requires strict coordination between the constituent cells whose action on the local scale must be orchestrated accurately to achieve a functional shape on the global scale. We present a theoretical model in which morphogenetic information is encoded only through a locally preferred curvature, but with cell dynamics which simultaneously ensures that these interactions globally achieve morphogenesis and correct cell-neighbor exchanges to avoid cell stretches. This is achieved by a cell-cell interaction potential that drives correct cell intercalation to reorganize the cell sheet dynamically during the deformation processes. We demonstrate morphogenesis of simple three-dimensional shapes and study the effects of fixed cell neighbor connectivity and noisy cell division.
Originalsprog | Engelsk |
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Artikelnummer | 023171 |
Tidsskrift | Physical Review Research |
Vol/bind | 4 |
Udgave nummer | 2 |
Antal sider | 10 |
ISSN | 2643-1564 |
DOI | |
Status | Udgivet - 31 maj 2022 |
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