Current understanding of thalamic structure and function in migraine
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Current understanding of thalamic structure and function in migraine. / Younis, Samaira; Hougaard, Anders; Noseda, Rodrigo; Ashina, Messoud.
I: Cephalalgia, Bind 39, Nr. 13, 2019, s. 1675-1682.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Current understanding of thalamic structure and function in migraine
AU - Younis, Samaira
AU - Hougaard, Anders
AU - Noseda, Rodrigo
AU - Ashina, Messoud
PY - 2019
Y1 - 2019
N2 - Objective: To review and discuss the literature on the role of thalamic structure and function in migraine. Discussion: The thalamus holds an important position in our understanding of allodynia, central sensitization and photophobia in migraine. Structural and functional findings suggest abnormal functional connectivity between the thalamus and various cortical regions pointing towards an altered pain processing in migraine. Pharmacological nociceptive modulation suggests that the thalamus is a potential drug target. Conclusion: A critical role for the thalamus in migraine-related allodynia and photophobia is well established. Additionally, the thalamus is most likely involved in the dysfunctional pain modulation and processing in migraine, but further research is needed to clarify the exact clinical implications of these findings.
AB - Objective: To review and discuss the literature on the role of thalamic structure and function in migraine. Discussion: The thalamus holds an important position in our understanding of allodynia, central sensitization and photophobia in migraine. Structural and functional findings suggest abnormal functional connectivity between the thalamus and various cortical regions pointing towards an altered pain processing in migraine. Pharmacological nociceptive modulation suggests that the thalamus is a potential drug target. Conclusion: A critical role for the thalamus in migraine-related allodynia and photophobia is well established. Additionally, the thalamus is most likely involved in the dysfunctional pain modulation and processing in migraine, but further research is needed to clarify the exact clinical implications of these findings.
KW - allodynia
KW - functional connectivity
KW - Migraine
KW - pain processing
KW - photophobia
KW - sensitization
KW - thalamus
U2 - 10.1177/0333102418791595
DO - 10.1177/0333102418791595
M3 - Review
C2 - 30079744
AN - SCOPUS:85052523503
VL - 39
SP - 1675
EP - 1682
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 13
ER -
ID: 235783550