Cu-catalyzed azide - Alkyne cycloaddition
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Cu-catalyzed azide - Alkyne cycloaddition. / Meldal, Morten; Tomøe, Christian Wenzel.
I: Chemical Reviews, Bind 108, Nr. 8, 08.2008, s. 2952-3015.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cu-catalyzed azide - Alkyne cycloaddition
AU - Meldal, Morten
AU - Tomøe, Christian Wenzel
PY - 2008/8
Y1 - 2008/8
N2 - The copper catalysis in the Huisgen reaction broadly known as the azide/ alkyne reaction or CuAAC reaction has been discussed. This simple and robust reaction, which involves clusters of Cu and ligands, has led to exclusive formation of the 1,4-isomer. It is vital to maintain a good concentration of Cu throughout the reaction medium particularly in the case of less reactive reaction components or dilute reactions. The ligands' role in protecting the copper from oxidation or disproportionation is also important. The ligands also influence the structure and equilibria of copper clusters and may promote the formation of the most catalytically active copper complexes. The CuAAC reaction may be designed to accommodate all types of protecting groups and reactive intermediates.
AB - The copper catalysis in the Huisgen reaction broadly known as the azide/ alkyne reaction or CuAAC reaction has been discussed. This simple and robust reaction, which involves clusters of Cu and ligands, has led to exclusive formation of the 1,4-isomer. It is vital to maintain a good concentration of Cu throughout the reaction medium particularly in the case of less reactive reaction components or dilute reactions. The ligands' role in protecting the copper from oxidation or disproportionation is also important. The ligands also influence the structure and equilibria of copper clusters and may promote the formation of the most catalytically active copper complexes. The CuAAC reaction may be designed to accommodate all types of protecting groups and reactive intermediates.
UR - http://www.scopus.com/inward/record.url?scp=51049094897&partnerID=8YFLogxK
U2 - 10.1021/cr0783479
DO - 10.1021/cr0783479
M3 - Review
C2 - 18698735
AN - SCOPUS:51049094897
VL - 108
SP - 2952
EP - 3015
JO - Chemical Reviews
JF - Chemical Reviews
SN - 0009-2665
IS - 8
ER -
ID: 321827018