CRISPR-based immune systems of the Sulfolobales: complexity and diversity

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

CRISPR-based immune systems of the Sulfolobales: complexity and diversity. / Garrett, Roger Antony; Shah, Shiraz Ali; Vestergaard, Gisle Alberg; Deng, Ling; Guðbergsdóttir, Sóley Ruth; Kenchappa, Chandra Shekar; Erdmann, Susanne; She, Qunxin.

I: Biochemical Society Transactions, Bind 39, Nr. 1, 2011, s. 51-57.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Garrett, RA, Shah, SA, Vestergaard, GA, Deng, L, Guðbergsdóttir, SR, Kenchappa, CS, Erdmann, S & She, Q 2011, 'CRISPR-based immune systems of the Sulfolobales: complexity and diversity', Biochemical Society Transactions, bind 39, nr. 1, s. 51-57. https://doi.org/10.1042/BST0390051

APA

Garrett, R. A., Shah, S. A., Vestergaard, G. A., Deng, L., Guðbergsdóttir, S. R., Kenchappa, C. S., Erdmann, S., & She, Q. (2011). CRISPR-based immune systems of the Sulfolobales: complexity and diversity. Biochemical Society Transactions, 39(1), 51-57. https://doi.org/10.1042/BST0390051

Vancouver

Garrett RA, Shah SA, Vestergaard GA, Deng L, Guðbergsdóttir SR, Kenchappa CS o.a. CRISPR-based immune systems of the Sulfolobales: complexity and diversity. Biochemical Society Transactions. 2011;39(1):51-57. https://doi.org/10.1042/BST0390051

Author

Garrett, Roger Antony ; Shah, Shiraz Ali ; Vestergaard, Gisle Alberg ; Deng, Ling ; Guðbergsdóttir, Sóley Ruth ; Kenchappa, Chandra Shekar ; Erdmann, Susanne ; She, Qunxin. / CRISPR-based immune systems of the Sulfolobales: complexity and diversity. I: Biochemical Society Transactions. 2011 ; Bind 39, Nr. 1. s. 51-57.

Bibtex

@article{c7a9c7ad326b4f05aa95f9c860003a96,
title = "CRISPR-based immune systems of the Sulfolobales: complexity and diversity",
abstract = "CRISPR (cluster of regularly interspaced palindromic repeats)/Cas and CRISPR/Cmr systems of Sulfolobus, targeting DNA and RNA respectively of invading viruses or plasmids are complex and diverse. We address their classification and functional diversity, and the wide sequence diversity of RAMP (repeat-associated mysterious protein)-motif containing proteins encoded in Cmr modules. Factors influencing maintenance of partially impaired CRISPR-based systems are discussed. The capacity for whole CRISPR transcripts to be generated despite the uptake of transcription signals within spacer sequences is considered. Targeting of protospacer regions of invading elements by Cas protein-crRNA (CRISPR RNA) complexes exhibit relatively low sequence stringency, but the integrity of protospacer-associated motifs appears to be important. Different mechanisms for circumventing or inactivating the immune systems are presented.",
author = "Garrett, {Roger Antony} and Shah, {Shiraz Ali} and Vestergaard, {Gisle Alberg} and Ling Deng and Gu{\dh}bergsd{\'o}ttir, {S{\'o}ley Ruth} and Kenchappa, {Chandra Shekar} and Susanne Erdmann and Qunxin She",
year = "2011",
doi = "10.1042/BST0390051",
language = "English",
volume = "39",
pages = "51--57",
journal = "Biochemical Society Transactions",
issn = "0300-5127",
publisher = "Portland Press Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - CRISPR-based immune systems of the Sulfolobales: complexity and diversity

AU - Garrett, Roger Antony

AU - Shah, Shiraz Ali

AU - Vestergaard, Gisle Alberg

AU - Deng, Ling

AU - Guðbergsdóttir, Sóley Ruth

AU - Kenchappa, Chandra Shekar

AU - Erdmann, Susanne

AU - She, Qunxin

PY - 2011

Y1 - 2011

N2 - CRISPR (cluster of regularly interspaced palindromic repeats)/Cas and CRISPR/Cmr systems of Sulfolobus, targeting DNA and RNA respectively of invading viruses or plasmids are complex and diverse. We address their classification and functional diversity, and the wide sequence diversity of RAMP (repeat-associated mysterious protein)-motif containing proteins encoded in Cmr modules. Factors influencing maintenance of partially impaired CRISPR-based systems are discussed. The capacity for whole CRISPR transcripts to be generated despite the uptake of transcription signals within spacer sequences is considered. Targeting of protospacer regions of invading elements by Cas protein-crRNA (CRISPR RNA) complexes exhibit relatively low sequence stringency, but the integrity of protospacer-associated motifs appears to be important. Different mechanisms for circumventing or inactivating the immune systems are presented.

AB - CRISPR (cluster of regularly interspaced palindromic repeats)/Cas and CRISPR/Cmr systems of Sulfolobus, targeting DNA and RNA respectively of invading viruses or plasmids are complex and diverse. We address their classification and functional diversity, and the wide sequence diversity of RAMP (repeat-associated mysterious protein)-motif containing proteins encoded in Cmr modules. Factors influencing maintenance of partially impaired CRISPR-based systems are discussed. The capacity for whole CRISPR transcripts to be generated despite the uptake of transcription signals within spacer sequences is considered. Targeting of protospacer regions of invading elements by Cas protein-crRNA (CRISPR RNA) complexes exhibit relatively low sequence stringency, but the integrity of protospacer-associated motifs appears to be important. Different mechanisms for circumventing or inactivating the immune systems are presented.

U2 - 10.1042/BST0390051

DO - 10.1042/BST0390051

M3 - Journal article

C2 - 21265746

VL - 39

SP - 51

EP - 57

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - 1

ER -

ID: 32646210