Control of mitosis, inflammation, and cell motility by limited leakage of lysosomes
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Control of mitosis, inflammation, and cell motility by limited leakage of lysosomes. / Stahl-Meyer, Jonathan; Stahl-Meyer, Kamilla; Jäättelä, Marja.
I: Current Opinion in Cell Biology, Bind 71, 2021, s. 29-37.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Control of mitosis, inflammation, and cell motility by limited leakage of lysosomes
AU - Stahl-Meyer, Jonathan
AU - Stahl-Meyer, Kamilla
AU - Jäättelä, Marja
PY - 2021
Y1 - 2021
N2 - Lysosomal membrane permeabilization and subsequent leakage of lysosomal hydrolases into the cytosol are considered as the major hallmarks of evolutionarily conserved lysosome-dependent cell death. Contradicting this postulate, new sensitive methods that can detect a minimal lysosomal membrane damage have demonstrated that lysosomal leakage does not necessarily equal cell death. Notably, cells are not only able to survive minor lysosomal membrane permeabilization, but some of their normal functions actually depend on leaked lysosomal hydrolases. Here we discuss emerging data suggesting that spatially and temporally controlled lysosomal leakage delivers lysosomal hydrolases to specific subcellular sites of action and controls at least three essential cellular processes, namely mitotic chromosome segregation, inflammatory signaling, and cellular motility.
AB - Lysosomal membrane permeabilization and subsequent leakage of lysosomal hydrolases into the cytosol are considered as the major hallmarks of evolutionarily conserved lysosome-dependent cell death. Contradicting this postulate, new sensitive methods that can detect a minimal lysosomal membrane damage have demonstrated that lysosomal leakage does not necessarily equal cell death. Notably, cells are not only able to survive minor lysosomal membrane permeabilization, but some of their normal functions actually depend on leaked lysosomal hydrolases. Here we discuss emerging data suggesting that spatially and temporally controlled lysosomal leakage delivers lysosomal hydrolases to specific subcellular sites of action and controls at least three essential cellular processes, namely mitotic chromosome segregation, inflammatory signaling, and cellular motility.
KW - Adhesion
KW - Cathepsins
KW - Chromosome segregation
KW - Inflammation
KW - Lysosomal membrane permeabilization
KW - Lysosomal storage disorders
KW - Lysosome
KW - Mitosis
KW - Motility
KW - NLRP3 inflammasome
U2 - 10.1016/j.ceb.2021.02.003
DO - 10.1016/j.ceb.2021.02.003
M3 - Review
C2 - 33684809
AN - SCOPUS:85101972995
VL - 71
SP - 29
EP - 37
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
ER -
ID: 258892394