Contemporary prevalence of diabetic neuropathies in individuals with type 1 and type 2 diabetes in a Danish tertiary outpatient clinic
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Contemporary prevalence of diabetic neuropathies in individuals with type 1 and type 2 diabetes in a Danish tertiary outpatient clinic. / Mizrak, Hatice Isik; Kufaishi, Huda; Hecquet, Sofie Korsgaard; Hansen, Tine Willum; Pop-Busui, Rodica; Rossing, Peter; Brock, Birgitte; Hansen, Christian Stevns.
I: Journal of Diabetes and its Complications, Bind 38, Nr. 6, 108761, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Contemporary prevalence of diabetic neuropathies in individuals with type 1 and type 2 diabetes in a Danish tertiary outpatient clinic
AU - Mizrak, Hatice Isik
AU - Kufaishi, Huda
AU - Hecquet, Sofie Korsgaard
AU - Hansen, Tine Willum
AU - Pop-Busui, Rodica
AU - Rossing, Peter
AU - Brock, Birgitte
AU - Hansen, Christian Stevns
N1 - Publisher Copyright: © 2024 Elsevier Inc.
PY - 2024
Y1 - 2024
N2 - Background: Population-based prevalence estimates of distal symmetric polyneuropathy (DPN) and diabetic autonomic neuropathy (DAN) are scares. Here we present neuropathy estimates and describe their overlap in a large cohort of people with type 1 and type 2 diabetes. Methods: In a large population of outpatient participants, DPN was assessed using vibration perception threshold, sural nerve function, touch, pain and thermal sensation. Definite DPN was defined by the Toronto Consensus Criteria. Painful DPN was defined by Douleur Neuropathique 4 Questions. DAN measures were: cardiovascular reflex tests, electrochemical skin conductance, and gastroparesis cardinal symptom index. Results: We included 822 individuals with type 1 (mean age (±SD) 54 ± 16 years, median [IQR] diabetes duration 26 [15–40] years) and 899 with type 2 diabetes (mean age 67 ± 11 years, median diabetes duration 16 [11−22] years). Definite DPN was prevalent in 54 % and 68 %, and painful DPN was in 5 % and 15 % of type 1 and type 2 participants, respectively. The prevalence of DAN varied between 6 and 39 % for type 1 and 9–49 % for type 2 diabetes. DPN without other neuropathy was present in 45 % with T1D and 50 % with T2D. Conclusion: The prevalence of DPN and DAN was high. DPN and DAN co-existed in only 50 % of cases.
AB - Background: Population-based prevalence estimates of distal symmetric polyneuropathy (DPN) and diabetic autonomic neuropathy (DAN) are scares. Here we present neuropathy estimates and describe their overlap in a large cohort of people with type 1 and type 2 diabetes. Methods: In a large population of outpatient participants, DPN was assessed using vibration perception threshold, sural nerve function, touch, pain and thermal sensation. Definite DPN was defined by the Toronto Consensus Criteria. Painful DPN was defined by Douleur Neuropathique 4 Questions. DAN measures were: cardiovascular reflex tests, electrochemical skin conductance, and gastroparesis cardinal symptom index. Results: We included 822 individuals with type 1 (mean age (±SD) 54 ± 16 years, median [IQR] diabetes duration 26 [15–40] years) and 899 with type 2 diabetes (mean age 67 ± 11 years, median diabetes duration 16 [11−22] years). Definite DPN was prevalent in 54 % and 68 %, and painful DPN was in 5 % and 15 % of type 1 and type 2 participants, respectively. The prevalence of DAN varied between 6 and 39 % for type 1 and 9–49 % for type 2 diabetes. DPN without other neuropathy was present in 45 % with T1D and 50 % with T2D. Conclusion: The prevalence of DPN and DAN was high. DPN and DAN co-existed in only 50 % of cases.
KW - Cardiovascular autonomic neuropathy
KW - Diabetic neuropathy
KW - Distal symmetric polyneuropathy
KW - Gastroparesis
KW - Painful neuropathy
KW - Prevalence
KW - Type 1 diabetes
KW - Type 2 diabetes
U2 - 10.1016/j.jdiacomp.2024.108761
DO - 10.1016/j.jdiacomp.2024.108761
M3 - Journal article
C2 - 38692039
AN - SCOPUS:85191856693
VL - 38
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 6
M1 - 108761
ER -
ID: 391619412