Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration

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Standard

Concise Review : Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration. / Rumman, Mohammad; Dhawan, Jyotsna; Kassem, Moustapha.

I: Stem Cells, Bind 33, Nr. 10, 10.2015, s. 2903-12.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rumman, M, Dhawan, J & Kassem, M 2015, 'Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration', Stem Cells, bind 33, nr. 10, s. 2903-12. https://doi.org/10.1002/stem.2056

APA

Rumman, M., Dhawan, J., & Kassem, M. (2015). Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration. Stem Cells, 33(10), 2903-12. https://doi.org/10.1002/stem.2056

Vancouver

Rumman M, Dhawan J, Kassem M. Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration. Stem Cells. 2015 okt.;33(10):2903-12. https://doi.org/10.1002/stem.2056

Author

Rumman, Mohammad ; Dhawan, Jyotsna ; Kassem, Moustapha. / Concise Review : Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration. I: Stem Cells. 2015 ; Bind 33, Nr. 10. s. 2903-12.

Bibtex

@article{a03dfbf43dea4252b3991024facde4c6,
title = "Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration",
abstract = "Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating, reversibly cell cycle-arrested state known as quiescence or G0. A key function of the quiescent state is to preserve stemness in ASCs by preventing precocious differentiation, and thus maintaining a pool of undifferentiated ASCs. Recent evidences suggest that quiescence is an actively maintained state and that excessive or defective quiescence may lead to compromised tissue regeneration or tumorigenesis. The aim of this review is to provide an update regarding the biological mechanisms of ASC quiescence and their role in tissue regeneration.",
keywords = "Adult Stem Cells, Cell Cycle Checkpoints, Cell Differentiation, Homeostasis, Humans, Regeneration, Wound Healing, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Mohammad Rumman and Jyotsna Dhawan and Moustapha Kassem",
note = "{\textcopyright} 2015 AlphaMed Press.",
year = "2015",
month = oct,
doi = "10.1002/stem.2056",
language = "English",
volume = "33",
pages = "2903--12",
journal = "Stem Cells",
issn = "1066-5099",
publisher = "AlphaMed Press, Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Concise Review

T2 - Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration

AU - Rumman, Mohammad

AU - Dhawan, Jyotsna

AU - Kassem, Moustapha

N1 - © 2015 AlphaMed Press.

PY - 2015/10

Y1 - 2015/10

N2 - Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating, reversibly cell cycle-arrested state known as quiescence or G0. A key function of the quiescent state is to preserve stemness in ASCs by preventing precocious differentiation, and thus maintaining a pool of undifferentiated ASCs. Recent evidences suggest that quiescence is an actively maintained state and that excessive or defective quiescence may lead to compromised tissue regeneration or tumorigenesis. The aim of this review is to provide an update regarding the biological mechanisms of ASC quiescence and their role in tissue regeneration.

AB - Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating, reversibly cell cycle-arrested state known as quiescence or G0. A key function of the quiescent state is to preserve stemness in ASCs by preventing precocious differentiation, and thus maintaining a pool of undifferentiated ASCs. Recent evidences suggest that quiescence is an actively maintained state and that excessive or defective quiescence may lead to compromised tissue regeneration or tumorigenesis. The aim of this review is to provide an update regarding the biological mechanisms of ASC quiescence and their role in tissue regeneration.

KW - Adult Stem Cells

KW - Cell Cycle Checkpoints

KW - Cell Differentiation

KW - Homeostasis

KW - Humans

KW - Regeneration

KW - Wound Healing

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1002/stem.2056

DO - 10.1002/stem.2056

M3 - Journal article

C2 - 26075660

VL - 33

SP - 2903

EP - 2912

JO - Stem Cells

JF - Stem Cells

SN - 1066-5099

IS - 10

ER -

ID: 176343218