Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes: the ADDITION-PRO study
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Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes : the ADDITION-PRO study. / Hansen, Anne-Louise Smidt; Carstensen, Bendix; Helge, Jørn Wulff; Johansen, Nanna B; Gram, Bibi; Christiansen, Jens S; Brage, Søren; Lauritzen, Torsten; Jørgensen, Marit Eika; Aadahl, Mette; Witte, Daniel R; ADDITION-Denmark Steering Committee.
I: Diabetes Care, Bind 36, Nr. 10, 10.2013, s. 3062-69.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes
T2 - the ADDITION-PRO study
AU - Hansen, Anne-Louise Smidt
AU - Carstensen, Bendix
AU - Helge, Jørn Wulff
AU - Johansen, Nanna B
AU - Gram, Bibi
AU - Christiansen, Jens S
AU - Brage, Søren
AU - Lauritzen, Torsten
AU - Jørgensen, Marit Eika
AU - Aadahl, Mette
AU - Witte, Daniel R
AU - ADDITION-Denmark Steering Committee
PY - 2013/10
Y1 - 2013/10
N2 - OBJECTIVE: Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) with detailed measures of glucose homeostasis.RESEARCH DESIGN AND METHODS: In 1,531 men and women, with low to high risk of developing type 2 diabetes, we measured 7 days of PAEE using a combined accelerometry and heart rate monitor (ActiHeart). Measures and indices of glucose homeostasis were derived from a 3-point oral glucose tolerance test in addition to measures of long-term glycemia (glycated hemoglobin A1c and advanced glycation end products). Associations of PAEE with glucose homeostasis markers were examined using linear regression models.RESULTS: Median age (IQR) was 66.6 years (62.1-71.6) (54% men) with a median ActiHeart wear time of 6.9 days (6.0-7.1) and PAEE level of 33.0 kJ/kg/day (23.5-46.1). In fully adjusted models, we found higher levels of PAEE to be positively associated with insulin sensitivity and negatively with insulin 2 h after glucose load (P<0.05).CONCLUSIONS: Even in an elderly population with low levels of PA, we found higher objectively measured PAEE levels to be associated with a more beneficial glucose metabolic profile. Although our findings are cross-sectional, they indicate that even without high-intensity exercise, increasing the overall level of PAEE slightly in an entire population at risk for developing type 2 diabetes may be a realistic and worthwhile goal to reach in order to achieve beneficial effect in terms of glucose metabolism.
AB - OBJECTIVE: Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) with detailed measures of glucose homeostasis.RESEARCH DESIGN AND METHODS: In 1,531 men and women, with low to high risk of developing type 2 diabetes, we measured 7 days of PAEE using a combined accelerometry and heart rate monitor (ActiHeart). Measures and indices of glucose homeostasis were derived from a 3-point oral glucose tolerance test in addition to measures of long-term glycemia (glycated hemoglobin A1c and advanced glycation end products). Associations of PAEE with glucose homeostasis markers were examined using linear regression models.RESULTS: Median age (IQR) was 66.6 years (62.1-71.6) (54% men) with a median ActiHeart wear time of 6.9 days (6.0-7.1) and PAEE level of 33.0 kJ/kg/day (23.5-46.1). In fully adjusted models, we found higher levels of PAEE to be positively associated with insulin sensitivity and negatively with insulin 2 h after glucose load (P<0.05).CONCLUSIONS: Even in an elderly population with low levels of PA, we found higher objectively measured PAEE levels to be associated with a more beneficial glucose metabolic profile. Although our findings are cross-sectional, they indicate that even without high-intensity exercise, increasing the overall level of PAEE slightly in an entire population at risk for developing type 2 diabetes may be a realistic and worthwhile goal to reach in order to achieve beneficial effect in terms of glucose metabolism.
KW - Accelerometry
KW - Aged
KW - Blood Glucose
KW - Diabetes Mellitus, Type 2
KW - Energy Metabolism
KW - Female
KW - Heart Rate
KW - Humans
KW - Male
KW - Middle Aged
KW - Motor Activity
U2 - 10.2337/dc12-2671
DO - 10.2337/dc12-2671
M3 - Journal article
C2 - 23757430
VL - 36
SP - 3062
EP - 3069
JO - Diabetes Care
JF - Diabetes Care
SN - 0149-5992
IS - 10
ER -
ID: 117869822