Collagen metabolism in obesity: the effect of weight loss
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Collagen metabolism in obesity : the effect of weight loss. / Rasmussen, M H; Jensen, L T; Andersen, T; Breum, L; Hilsted, J.
I: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, Bind 19, Nr. 9, 09.1995, s. 659-63.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Collagen metabolism in obesity
T2 - the effect of weight loss
AU - Rasmussen, M H
AU - Jensen, L T
AU - Andersen, T
AU - Breum, L
AU - Hilsted, J
PY - 1995/9
Y1 - 1995/9
N2 - OBJECTIVE: To investigate the impact of obesity, fat distribution and weight loss on collagen turnover using serum concentrations of the carboxyterminal propeptide of type I procollagen (S-PICP) and the aminoterminal propeptide of type III pro-collagen (S-PIIINP) as markers for collagen turnover.DESIGN: Blood samples were obtained once at baseline, and after 8 and 16 weeks of dietary treatment (5.0 MJ/day diet).SETTING: Outpatient clinic of Hvidovre University Hospital.MAIN OUTCOME MEASURES: S-PICP, S-PIIINP, fat distribution and weight loss.RESULTS: S-PIIINP was associated with body weight (r = 0.37; P = 0.004), height (r = 0.27; P = 0.04), waist circumference (r = 0.35; P = 0.007), as well as with WHR (r = 0.33; P = 0.01) and was inversely correlated to age (r = -0.40; P = 0.002). Compared with randomly selected controls from a large pool of healthy volunteers, the obese patients had elevated S-PIIINP values before as well as during weight loss, whereas S-PICP levels were within the normal range and did not correlate with any anthropometric measures. The average weight loss after 16 weeks dietary treatment was 8.1 kg (s.d. = 0.8). S-PIIINP decreased during the 16 weeks of energy restriction (P < 0.05) and changes in S-PIIINP was correlated to body weight loss (r = 0.32; P < 0.05) and to changes in waist circumference (r = 0.34; P < 0.05) as well as changes in WHR (r = 0.30; P < 0.05).CONCLUSION: S-PIIINP is elevated in obesity and associated with body fat distribution, suggesting an increased turnover of type III collagen related to obesity in general and to abdominal obesity in particular. S-PIIINP levels decreases during weight loss in obese subjects, whereas S-PICP levels seems un-related to obesity and weight loss.
AB - OBJECTIVE: To investigate the impact of obesity, fat distribution and weight loss on collagen turnover using serum concentrations of the carboxyterminal propeptide of type I procollagen (S-PICP) and the aminoterminal propeptide of type III pro-collagen (S-PIIINP) as markers for collagen turnover.DESIGN: Blood samples were obtained once at baseline, and after 8 and 16 weeks of dietary treatment (5.0 MJ/day diet).SETTING: Outpatient clinic of Hvidovre University Hospital.MAIN OUTCOME MEASURES: S-PICP, S-PIIINP, fat distribution and weight loss.RESULTS: S-PIIINP was associated with body weight (r = 0.37; P = 0.004), height (r = 0.27; P = 0.04), waist circumference (r = 0.35; P = 0.007), as well as with WHR (r = 0.33; P = 0.01) and was inversely correlated to age (r = -0.40; P = 0.002). Compared with randomly selected controls from a large pool of healthy volunteers, the obese patients had elevated S-PIIINP values before as well as during weight loss, whereas S-PICP levels were within the normal range and did not correlate with any anthropometric measures. The average weight loss after 16 weeks dietary treatment was 8.1 kg (s.d. = 0.8). S-PIIINP decreased during the 16 weeks of energy restriction (P < 0.05) and changes in S-PIIINP was correlated to body weight loss (r = 0.32; P < 0.05) and to changes in waist circumference (r = 0.34; P < 0.05) as well as changes in WHR (r = 0.30; P < 0.05).CONCLUSION: S-PIIINP is elevated in obesity and associated with body fat distribution, suggesting an increased turnover of type III collagen related to obesity in general and to abdominal obesity in particular. S-PIIINP levels decreases during weight loss in obese subjects, whereas S-PICP levels seems un-related to obesity and weight loss.
KW - Adult
KW - Anthropometry
KW - Body Constitution
KW - Body Weight
KW - Collagen
KW - Fatty Acids, Nonesterified
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Obesity
KW - Peptide Fragments
KW - Procollagen
KW - Weight Loss
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
M3 - Journal article
C2 - 8574277
VL - 19
SP - 659
EP - 663
JO - International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
JF - International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
IS - 9
ER -
ID: 168533008