Coeliac disease in children: a social epidemiological study in Sweden
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Coeliac disease in children : a social epidemiological study in Sweden. / Clinical Sciences, Malmö, Lund University, Department; Björck, Sara; Lynch, Kristian F; Ohlsson, Henrik; Agardh, Daniel; Merlo, Juan.
I: Acta paediatrica (Oslo, Norway : 1992), Bind 101, Nr. 2, 02.2012, s. 185-91.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Coeliac disease in children
T2 - a social epidemiological study in Sweden
AU - Clinical Sciences, Malmö, Lund University, Department
AU - Björck, Sara
AU - Lynch, Kristian F
AU - Ohlsson, Henrik
AU - Agardh, Daniel
AU - Merlo, Juan
N1 - © 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.
PY - 2012/2
Y1 - 2012/2
N2 - AIM: Little is known on the possible existence of socioeconomic and geographical differences in early coeliac disease (CD) risk. Therefore, we investigated these aspects in children before age two.METHODS: Linking the Swedish Medical Birth Registry to several other national registries, we identified all singletons born in Sweden from 1987 to 1993 (n = 792,401) and followed them until 2 years of age to identify cases of CD. Applying multilevel logistic regression analysis, we investigated the association between socioeconomic position (SEP) and CD in children and also whether a possible geographical variation in CD risk was explained by individual characteristics.RESULTS: Low SEP was associated with CD in boys OR 1.37 (95% CI 1.03-1.82), but not in girls OR 0.87 (95% CI 0.68-1.12). We found a considerable geographical variation in disease risk (i.e. intra-municipality correlation ≈ 10%) that was not explained by individual characteristics.CONCLUSIONS: Low SEP is associated with CD in boys but not in girls. Also, CD appears to be conditioned by geographical area of residence. While our study represents an innovative contribution to the epidemiology of CD in children, the reasons for the observed geographical and socioeconomic differences could be speculated but are still unknown.
AB - AIM: Little is known on the possible existence of socioeconomic and geographical differences in early coeliac disease (CD) risk. Therefore, we investigated these aspects in children before age two.METHODS: Linking the Swedish Medical Birth Registry to several other national registries, we identified all singletons born in Sweden from 1987 to 1993 (n = 792,401) and followed them until 2 years of age to identify cases of CD. Applying multilevel logistic regression analysis, we investigated the association between socioeconomic position (SEP) and CD in children and also whether a possible geographical variation in CD risk was explained by individual characteristics.RESULTS: Low SEP was associated with CD in boys OR 1.37 (95% CI 1.03-1.82), but not in girls OR 0.87 (95% CI 0.68-1.12). We found a considerable geographical variation in disease risk (i.e. intra-municipality correlation ≈ 10%) that was not explained by individual characteristics.CONCLUSIONS: Low SEP is associated with CD in boys but not in girls. Also, CD appears to be conditioned by geographical area of residence. While our study represents an innovative contribution to the epidemiology of CD in children, the reasons for the observed geographical and socioeconomic differences could be speculated but are still unknown.
KW - Celiac Disease/epidemiology
KW - Child, Preschool
KW - Data Collection
KW - Female
KW - Humans
KW - Infant
KW - Male
KW - Prospective Studies
KW - Registries
KW - Residence Characteristics/statistics & numerical data
KW - Risk Factors
KW - Sex Distribution
KW - Social Class
KW - Sweden/epidemiology
U2 - 10.1111/j.1651-2227.2011.02434.x
DO - 10.1111/j.1651-2227.2011.02434.x
M3 - Journal article
C2 - 21824189
VL - 101
SP - 185
EP - 191
JO - Acta Paediatrica
JF - Acta Paediatrica
SN - 0803-5253
IS - 2
ER -
ID: 365307260