TY - JOUR

T1 - Clinical characteristics and predictors of mechanical ventilation in patients with COVID-19 hospitalized in Southern Brazil

AU - Nader Bastos, Gisele Alsina

AU - Zimmermann de Azambuja, Aline

AU - Polanczyk, Carisi Anne

AU - Dalmas Gräf, Débora

AU - Weschenfelder Zorzo, Isabelle

AU - Gasparetto Macari, Juçara

AU - Schnor Haygert, Lúcia

AU - Nasi, Luiz Antônio

AU - Basso Gazzana, Marcelo

AU - Bessel, Marina

AU - Pitrez, Paulo Márcio

AU - Pinheiro de Oliveira, Roselaine

AU - Comerlato Scotta, Marcelo

PY - 2020

Y1 - 2020

N2 - Objective: This study aims to describe the clinical characteristics and predictors of mechanical ventilation of adult inpatients with COVID-19 in a single center.Methods: A retrospective cohort study was performed and included adult inpatients hospitalized from March 17th to May 3rd, 2020, who were diagnosed with SARS-CoV-2 infection. Clinical and demographic characteristics were extracted from electronic medical records.Results: Overall, 88 consecutive patients were included in this study. The median age of the patients was 63 years (IQR 49 - 71); 59 (67%) were male, 65 (86%) had a college degree and 67 (76%) had at least one comorbidity. Twenty-nine (33%) patients were admitted to the intensive care unit, 18 (20%) patients needed mechanical ventilation, and 9 (10.2%) died during hospitalization. The median length of stay in the intensive care unit and the median duration of mechanical ventilation was 23 and 29.5 days, respectively. An age ≥ 65 years was an independent risk factor for mechanical ventilation (OR 8.4 95%CI 1.3 - 55.6 p = 0.02).Conclusion: Our findings describe the first wave of Brazilian patients hospitalized for COVID-19. Age was the strongest predictor of respiratory insufficiency and the need for mechanical ventilation in our population.

AB - Objective: This study aims to describe the clinical characteristics and predictors of mechanical ventilation of adult inpatients with COVID-19 in a single center.Methods: A retrospective cohort study was performed and included adult inpatients hospitalized from March 17th to May 3rd, 2020, who were diagnosed with SARS-CoV-2 infection. Clinical and demographic characteristics were extracted from electronic medical records.Results: Overall, 88 consecutive patients were included in this study. The median age of the patients was 63 years (IQR 49 - 71); 59 (67%) were male, 65 (86%) had a college degree and 67 (76%) had at least one comorbidity. Twenty-nine (33%) patients were admitted to the intensive care unit, 18 (20%) patients needed mechanical ventilation, and 9 (10.2%) died during hospitalization. The median length of stay in the intensive care unit and the median duration of mechanical ventilation was 23 and 29.5 days, respectively. An age ≥ 65 years was an independent risk factor for mechanical ventilation (OR 8.4 95%CI 1.3 - 55.6 p = 0.02).Conclusion: Our findings describe the first wave of Brazilian patients hospitalized for COVID-19. Age was the strongest predictor of respiratory insufficiency and the need for mechanical ventilation in our population.

UR - https://doi.org/10.5935/0103-507X.20200082

U2 - 10.5935/0103-507x.20200082

DO - 10.5935/0103-507x.20200082

M3 - Journal article

VL - 32

SP - 487

EP - 492

JO - Revista Brasileira de Terapia Intensiva

JF - Revista Brasileira de Terapia Intensiva

SN - 0103-507X

IS - 4

ER -