Circadian rhythms of mineral metabolism in chronic kidney disease-mineral bone disorder
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Circadian rhythms of mineral metabolism in chronic kidney disease-mineral bone disorder. / Egstrand, Søren; Olgaard, Klaus; Lewin, Ewa.
I: Current Opinion in Nephrology and Hypertension, Bind 29, Nr. 4, 2020, s. 367-377.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Circadian rhythms of mineral metabolism in chronic kidney disease-mineral bone disorder
AU - Egstrand, Søren
AU - Olgaard, Klaus
AU - Lewin, Ewa
PY - 2020
Y1 - 2020
N2 - Purpose of reviewThe circadian rhythms have a systemic impact on all aspects of physiology. Kidney diseases are associated with extremely high-cardiovascular mortality, related to chronic kidney disease-mineral bone disorder (CKD-MBD), involving bone, parathyroids and vascular calcification. Disruption of circadian rhythms may cause serious health problems, contributing to development of cardiovascular diseases, metabolic syndrome, cancer, organ fibrosis, osteopenia and aging. Evidence of disturbed circadian rhythms in CKD-MBD parameters and organs involved is emerging and will be discussed in this review.Recent findingsKidney injury induces unstable behavioral circadian rhythm. Potentially, uremic toxins may affect the master-pacemaker of circadian rhythm in hypothalamus. In CKD disturbances in the circadian rhythms of CKD-MBD plasma-parameters, activin A, fibroblast growth factor 23, parathyroid hormone, phosphate have been demonstrated. A molecular circadian clock is also expressed in peripheral tissues, involved in CKD-MBD; vasculature, parathyroids and bone. Expression of the core circadian clock genes in the different tissues is disrupted in CKD-MBD.SummaryDisturbed circadian rhythms is a novel feature of CKD-MBD. There is a need to establish which specific input determines the phase of the local molecular clock and to characterize its regulation and deregulation in tissues involved in CKD-MBD. Finally, it is important to establish what are the implications for treatment including the potential applications for chronotherapy.
AB - Purpose of reviewThe circadian rhythms have a systemic impact on all aspects of physiology. Kidney diseases are associated with extremely high-cardiovascular mortality, related to chronic kidney disease-mineral bone disorder (CKD-MBD), involving bone, parathyroids and vascular calcification. Disruption of circadian rhythms may cause serious health problems, contributing to development of cardiovascular diseases, metabolic syndrome, cancer, organ fibrosis, osteopenia and aging. Evidence of disturbed circadian rhythms in CKD-MBD parameters and organs involved is emerging and will be discussed in this review.Recent findingsKidney injury induces unstable behavioral circadian rhythm. Potentially, uremic toxins may affect the master-pacemaker of circadian rhythm in hypothalamus. In CKD disturbances in the circadian rhythms of CKD-MBD plasma-parameters, activin A, fibroblast growth factor 23, parathyroid hormone, phosphate have been demonstrated. A molecular circadian clock is also expressed in peripheral tissues, involved in CKD-MBD; vasculature, parathyroids and bone. Expression of the core circadian clock genes in the different tissues is disrupted in CKD-MBD.SummaryDisturbed circadian rhythms is a novel feature of CKD-MBD. There is a need to establish which specific input determines the phase of the local molecular clock and to characterize its regulation and deregulation in tissues involved in CKD-MBD. Finally, it is important to establish what are the implications for treatment including the potential applications for chronotherapy.
KW - activin A
KW - fibroblast growth factor 23
KW - klotho
KW - parathyroid
KW - renal osteodystrophy
KW - vascular calcification
U2 - 10.1097/MNH.0000000000000611
DO - 10.1097/MNH.0000000000000611
M3 - Review
C2 - 32452917
AN - SCOPUS:85085586117
VL - 29
SP - 367
EP - 377
JO - Current Opinion in Nephrology & Hypertension
JF - Current Opinion in Nephrology & Hypertension
SN - 1062-4821
IS - 4
ER -
ID: 258400870