Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Background: Psoriasis is a common inflammatory skin disease associated with several immune-mediated inflammatory diseases (IMIDs); however, little is known of the chronology of disease development. Objective: To investigate the chronology of IMIDs relative to psoriasis. Methods: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n = 10,923) and general population controls (n = 109,230). Results: Approximately 20% of patients with psoriasis developed ≥1 IMID, with a 5-fold increased risk compared with the general population. Most IMIDs were diagnosed before psoriasis, except for psoriatic arthritis. Psoriasis was significantly associated with having multiple IMIDs (odds ratio 15.2, 95% confidence interval 11.6-20.0). Human leukocyte antigen B27 positivity was significantly more frequent among psoriasis patients. Limitations: Clinical measurements were unavailable. Conclusion: IMIDs occur frequently in patients with psoriasis and most are diagnosed before psoriasis. The observed chronology might represent important mechanisms of disease development.
Originalsprog | Engelsk |
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Tidsskrift | Journal of the American Academy of Dermatology |
Vol/bind | 81 |
Udgave nummer | 6 |
Sider (fra-til) | 1283-1291 |
ISSN | 0190-9622 |
DOI | |
Status | Udgivet - dec. 2019 |
ID: 241989332