Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Smoking rates among depressed individuals is higher than among healthy subjects, and nicotine alleviates depressive symptoms. Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. In mice, acute nicotine administration enhances the activity of antidepressants in the mouse forced swim (mFST) and tail suspension tests. Here, we investigated if this action of nicotine is also reflected in a chronic treatment regimen.
Originalsprog | Engelsk |
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Tidsskrift | Psychopharmacology |
Vol/bind | 205 |
Udgave nummer | 3 |
Sider (fra-til) | 517-28 |
Antal sider | 12 |
ISSN | 0033-3158 |
DOI | |
Status | Udgivet - 1 aug. 2009 |
ID: 34329132