Chronic alcohol induces subcircuit-specific striatonigral plasticity enhancing the sensorimotor basal ganglia role in action execution

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Standard

Chronic alcohol induces subcircuit-specific striatonigral plasticity enhancing the sensorimotor basal ganglia role in action execution. / Sitzia, Giacomo; Bariselli, Sebastiano; Gracias, Alexa; Lovinger, David M.

I: Science Advances, Bind 10, Nr. 26, eadm6951, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Sitzia, G, Bariselli, S, Gracias, A & Lovinger, DM 2024, 'Chronic alcohol induces subcircuit-specific striatonigral plasticity enhancing the sensorimotor basal ganglia role in action execution', Science Advances, bind 10, nr. 26, eadm6951. https://doi.org/10.1126/sciadv.adm6951

APA

Sitzia, G., Bariselli, S., Gracias, A., & Lovinger, D. M. (2024). Chronic alcohol induces subcircuit-specific striatonigral plasticity enhancing the sensorimotor basal ganglia role in action execution. Science Advances, 10(26), [eadm6951]. https://doi.org/10.1126/sciadv.adm6951

Vancouver

Sitzia G, Bariselli S, Gracias A, Lovinger DM. Chronic alcohol induces subcircuit-specific striatonigral plasticity enhancing the sensorimotor basal ganglia role in action execution. Science Advances. 2024;10(26). eadm6951. https://doi.org/10.1126/sciadv.adm6951

Author

Sitzia, Giacomo ; Bariselli, Sebastiano ; Gracias, Alexa ; Lovinger, David M. / Chronic alcohol induces subcircuit-specific striatonigral plasticity enhancing the sensorimotor basal ganglia role in action execution. I: Science Advances. 2024 ; Bind 10, Nr. 26.

Bibtex

@article{d8179ba7f1c24bcc9841efb0636a5466,
title = "Chronic alcohol induces subcircuit-specific striatonigral plasticity enhancing the sensorimotor basal ganglia role in action execution",
abstract = "Functional deficits in basal ganglia (BG) circuits contribute to cognitive and motor dysfunctions in alcohol use disorder. Chronic alcohol exposure alters synaptic function and neuronal excitability in the dorsal striatum, but it remains unclear how it affects BG output that is mediated by the substantia nigra pars reticulata (SNr). Here, we describe a neuronal subpopulation-specific synaptic organization of striatal and subthalamic (STN) inputs to the medial and lateral SNr. Chronic alcohol exposure (CIE) potentiated dorsolateral striatum (DLS) inputs but did not change dorsomedial striatum and STN inputs to the SNr. Chemogenetic inhibition of DLS direct pathway neurons revealed an enhanced role for DLS direct pathway neurons in execution of an instrumental lever-pressing task. Overall, we reveal a subregion-specific organization of striatal and subthalamic inputs onto the medial and lateral SNr and find that potentiated DLS-SNr inputs are accompanied by altered BG control of action execution following CIE.",
author = "Giacomo Sitzia and Sebastiano Bariselli and Alexa Gracias and Lovinger, {David M.}",
year = "2024",
doi = "10.1126/sciadv.adm6951",
language = "English",
volume = "10",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "26",

}

RIS

TY - JOUR

T1 - Chronic alcohol induces subcircuit-specific striatonigral plasticity enhancing the sensorimotor basal ganglia role in action execution

AU - Sitzia, Giacomo

AU - Bariselli, Sebastiano

AU - Gracias, Alexa

AU - Lovinger, David M.

PY - 2024

Y1 - 2024

N2 - Functional deficits in basal ganglia (BG) circuits contribute to cognitive and motor dysfunctions in alcohol use disorder. Chronic alcohol exposure alters synaptic function and neuronal excitability in the dorsal striatum, but it remains unclear how it affects BG output that is mediated by the substantia nigra pars reticulata (SNr). Here, we describe a neuronal subpopulation-specific synaptic organization of striatal and subthalamic (STN) inputs to the medial and lateral SNr. Chronic alcohol exposure (CIE) potentiated dorsolateral striatum (DLS) inputs but did not change dorsomedial striatum and STN inputs to the SNr. Chemogenetic inhibition of DLS direct pathway neurons revealed an enhanced role for DLS direct pathway neurons in execution of an instrumental lever-pressing task. Overall, we reveal a subregion-specific organization of striatal and subthalamic inputs onto the medial and lateral SNr and find that potentiated DLS-SNr inputs are accompanied by altered BG control of action execution following CIE.

AB - Functional deficits in basal ganglia (BG) circuits contribute to cognitive and motor dysfunctions in alcohol use disorder. Chronic alcohol exposure alters synaptic function and neuronal excitability in the dorsal striatum, but it remains unclear how it affects BG output that is mediated by the substantia nigra pars reticulata (SNr). Here, we describe a neuronal subpopulation-specific synaptic organization of striatal and subthalamic (STN) inputs to the medial and lateral SNr. Chronic alcohol exposure (CIE) potentiated dorsolateral striatum (DLS) inputs but did not change dorsomedial striatum and STN inputs to the SNr. Chemogenetic inhibition of DLS direct pathway neurons revealed an enhanced role for DLS direct pathway neurons in execution of an instrumental lever-pressing task. Overall, we reveal a subregion-specific organization of striatal and subthalamic inputs onto the medial and lateral SNr and find that potentiated DLS-SNr inputs are accompanied by altered BG control of action execution following CIE.

U2 - 10.1126/sciadv.adm6951

DO - 10.1126/sciadv.adm6951

M3 - Journal article

C2 - 38941461

AN - SCOPUS:85197115796

VL - 10

JO - Science advances

JF - Science advances

SN - 2375-2548

IS - 26

M1 - eadm6951

ER -

ID: 398062852