Cheek Numbness Caused by Perineural Tumor Invasion of the Infraorbital Nerve: A Review of 3 Diagnostically Challenging Cases
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Cheek Numbness Caused by Perineural Tumor Invasion of the Infraorbital Nerve : A Review of 3 Diagnostically Challenging Cases. / Okholm, Cecilie; Frendø, Martin; Kiss, Katalin; von Buchwald, Christian.
I: American Journal of Case Reports, Bind 19, 2018, s. 296-300.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cheek Numbness Caused by Perineural Tumor Invasion of the Infraorbital Nerve
T2 - A Review of 3 Diagnostically Challenging Cases
AU - Okholm, Cecilie
AU - Frendø, Martin
AU - Kiss, Katalin
AU - von Buchwald, Christian
PY - 2018
Y1 - 2018
N2 - BACKGROUND Facial pain and numbness are common symptoms with a variety of causes; rarely, it is an initial sign of perineural infiltration of malignant tumors. CASE REPORT Here, we report 3 challenging cases, all presenting with pain and numbness of the cheek as the primary symptoms. Upon referral, there were neither signs of severe illness nor information about previous malignant diseases, while the diagnostic work-ups revealed additional involvement of the facial nerve in 2 of the cases. Surgical removal of the perineural tissue around the infraorbital nerve revealed perineural invasion by a squamous carcinoma. A more thorough review of their medical histories revealed that all 3 of the patients had had previous facial skin cancer. CONCLUSIONS Numbness or pain in the cheek may represent perineural invasion of a facial cutaneous carcinoma. This review of 3 cases addresses the necessity of identifying previous incidences of skin cancer in the medical history.
AB - BACKGROUND Facial pain and numbness are common symptoms with a variety of causes; rarely, it is an initial sign of perineural infiltration of malignant tumors. CASE REPORT Here, we report 3 challenging cases, all presenting with pain and numbness of the cheek as the primary symptoms. Upon referral, there were neither signs of severe illness nor information about previous malignant diseases, while the diagnostic work-ups revealed additional involvement of the facial nerve in 2 of the cases. Surgical removal of the perineural tissue around the infraorbital nerve revealed perineural invasion by a squamous carcinoma. A more thorough review of their medical histories revealed that all 3 of the patients had had previous facial skin cancer. CONCLUSIONS Numbness or pain in the cheek may represent perineural invasion of a facial cutaneous carcinoma. This review of 3 cases addresses the necessity of identifying previous incidences of skin cancer in the medical history.
KW - Aged
KW - Biopsy
KW - Carcinoma, Squamous Cell/complications
KW - Cheek/innervation
KW - Diagnosis, Differential
KW - Facial Neoplasms/complications
KW - Humans
KW - Hypesthesia/diagnosis
KW - Male
KW - Middle Aged
KW - Neoplasm Invasiveness
KW - Skin/pathology
U2 - 10.12659/AJCR.907034
DO - 10.12659/AJCR.907034
M3 - Journal article
C2 - 29540660
VL - 19
SP - 296
EP - 300
JO - American Journal of Case Reports
JF - American Journal of Case Reports
SN - 1941-5923
ER -
ID: 218177933