Changes in collagen metabolites in serum after cemented hip and knee arthroplasty

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Changes in collagen metabolites in serum after cemented hip and knee arthroplasty. / Joerring, S; Jensen, L T.

I: Archives of Orthopaedic and Trauma Surgery, Bind 112, Nr. 3, 1993, s. 139-41.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Joerring, S & Jensen, LT 1993, 'Changes in collagen metabolites in serum after cemented hip and knee arthroplasty', Archives of Orthopaedic and Trauma Surgery, bind 112, nr. 3, s. 139-41. https://doi.org/10.1007/BF00449991

APA

Joerring, S., & Jensen, L. T. (1993). Changes in collagen metabolites in serum after cemented hip and knee arthroplasty. Archives of Orthopaedic and Trauma Surgery, 112(3), 139-41. https://doi.org/10.1007/BF00449991

Vancouver

Joerring S, Jensen LT. Changes in collagen metabolites in serum after cemented hip and knee arthroplasty. Archives of Orthopaedic and Trauma Surgery. 1993;112(3):139-41. https://doi.org/10.1007/BF00449991

Author

Joerring, S ; Jensen, L T. / Changes in collagen metabolites in serum after cemented hip and knee arthroplasty. I: Archives of Orthopaedic and Trauma Surgery. 1993 ; Bind 112, Nr. 3. s. 139-41.

Bibtex

@article{28719732677340f6a52352813be791db,
title = "Changes in collagen metabolites in serum after cemented hip and knee arthroplasty",
abstract = "Markers of types I and III collagen turnover were measured in serial blood samples collected preoperatively and 60 days after surgery in 13 patients undergoing cemented total hip arthroplasty and 11 patients undergoing cemented total knee arthroplasty. The markers were the carboxyterminal extension peptide of type I procollagen (PICP) and the aminoterminal extension peptide of type III procollagen (PIIINP). The course of serum PICP and serum PIIINP in the two treatment groups were uniform. Serum PICP showed an initial fall on day 4, thereafter increasing up to days 14-28 and was still elevated on day 60. Serum PIIINP was increased on day 4, reaching its maximum on days 14-21, and thereafter declined but remained elevated above initial values. Serum osteocalcin, a serological marker of osteoblast activity, showed no significant changes in the two treatment groups during the observational period. We suggest that the changes in serum PICP and serum PIIINP reflect collagen formation in healing soft connective tissue 60 days after cemented hip or knee arthroplasty.",
keywords = "Aged, Aged, 80 and over, Cementation, Female, Hip Prosthesis, Humans, Knee Prosthesis, Male, Osteocalcin, Peptide Fragments, Procollagen, Journal Article, Research Support, Non-U.S. Gov't",
author = "S Joerring and Jensen, {L T}",
year = "1993",
doi = "10.1007/BF00449991",
language = "English",
volume = "112",
pages = "139--41",
journal = "Archives of Orthopaedic and Trauma Surgery",
issn = "0936-8051",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Changes in collagen metabolites in serum after cemented hip and knee arthroplasty

AU - Joerring, S

AU - Jensen, L T

PY - 1993

Y1 - 1993

N2 - Markers of types I and III collagen turnover were measured in serial blood samples collected preoperatively and 60 days after surgery in 13 patients undergoing cemented total hip arthroplasty and 11 patients undergoing cemented total knee arthroplasty. The markers were the carboxyterminal extension peptide of type I procollagen (PICP) and the aminoterminal extension peptide of type III procollagen (PIIINP). The course of serum PICP and serum PIIINP in the two treatment groups were uniform. Serum PICP showed an initial fall on day 4, thereafter increasing up to days 14-28 and was still elevated on day 60. Serum PIIINP was increased on day 4, reaching its maximum on days 14-21, and thereafter declined but remained elevated above initial values. Serum osteocalcin, a serological marker of osteoblast activity, showed no significant changes in the two treatment groups during the observational period. We suggest that the changes in serum PICP and serum PIIINP reflect collagen formation in healing soft connective tissue 60 days after cemented hip or knee arthroplasty.

AB - Markers of types I and III collagen turnover were measured in serial blood samples collected preoperatively and 60 days after surgery in 13 patients undergoing cemented total hip arthroplasty and 11 patients undergoing cemented total knee arthroplasty. The markers were the carboxyterminal extension peptide of type I procollagen (PICP) and the aminoterminal extension peptide of type III procollagen (PIIINP). The course of serum PICP and serum PIIINP in the two treatment groups were uniform. Serum PICP showed an initial fall on day 4, thereafter increasing up to days 14-28 and was still elevated on day 60. Serum PIIINP was increased on day 4, reaching its maximum on days 14-21, and thereafter declined but remained elevated above initial values. Serum osteocalcin, a serological marker of osteoblast activity, showed no significant changes in the two treatment groups during the observational period. We suggest that the changes in serum PICP and serum PIIINP reflect collagen formation in healing soft connective tissue 60 days after cemented hip or knee arthroplasty.

KW - Aged

KW - Aged, 80 and over

KW - Cementation

KW - Female

KW - Hip Prosthesis

KW - Humans

KW - Knee Prosthesis

KW - Male

KW - Osteocalcin

KW - Peptide Fragments

KW - Procollagen

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1007/BF00449991

DO - 10.1007/BF00449991

M3 - Journal article

C2 - 8323844

VL - 112

SP - 139

EP - 141

JO - Archives of Orthopaedic and Trauma Surgery

JF - Archives of Orthopaedic and Trauma Surgery

SN - 0936-8051

IS - 3

ER -

ID: 168533265