CGRP in human models of primary headaches
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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CGRP in human models of primary headaches. / Ashina, Håkan; Schytz, Henrik Winther; Ashina, Messoud.
I: Cephalalgia : an international journal of headache, Bind 38, Nr. 2, 2018, s. 353-360.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - CGRP in human models of primary headaches
AU - Ashina, Håkan
AU - Schytz, Henrik Winther
AU - Ashina, Messoud
PY - 2018
Y1 - 2018
N2 - Objective To review the role of CGRP in human models of primary headaches and to discuss methodological aspects and future directions. Discussion Provocation experiments demonstrated a heterogeneous CGRP migraine response in migraine patients. Conflicting CGRP plasma results in the provocation experiments are likely due to assay variation; therefore, proper validation and standardization of an assay is needed. To what extent CGRP is involved in tension-type headache and cluster headache is unknown. Conclusion Human models of primary headaches have elucidated the role of CGRP in headache pathophysiology and sparked great interest in developing new treatment strategies using CGRP antagonists and antibodies. Future studies applying more refined human experimental models should identify biomarkers of CGRP-induced primary headache and reveal whether CGRP provocation experiments could be used to predict efficacy of CGRP antagonists in migraine patients.
AB - Objective To review the role of CGRP in human models of primary headaches and to discuss methodological aspects and future directions. Discussion Provocation experiments demonstrated a heterogeneous CGRP migraine response in migraine patients. Conflicting CGRP plasma results in the provocation experiments are likely due to assay variation; therefore, proper validation and standardization of an assay is needed. To what extent CGRP is involved in tension-type headache and cluster headache is unknown. Conclusion Human models of primary headaches have elucidated the role of CGRP in headache pathophysiology and sparked great interest in developing new treatment strategies using CGRP antagonists and antibodies. Future studies applying more refined human experimental models should identify biomarkers of CGRP-induced primary headache and reveal whether CGRP provocation experiments could be used to predict efficacy of CGRP antagonists in migraine patients.
KW - Analgesics/pharmacology
KW - Biomarkers/metabolism
KW - Calcitonin Gene-Related Peptide/antagonists & inhibitors
KW - Cluster Headache/diagnosis
KW - Humans
KW - Migraine Disorders/diagnosis
KW - Tension-Type Headache/diagnosis
U2 - 10.1177/0333102416684344
DO - 10.1177/0333102416684344
M3 - Review
C2 - 27940880
VL - 38
SP - 353
EP - 360
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 2
ER -
ID: 215867602