CGRP in Human Models of Migraine
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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CGRP in Human Models of Migraine. / Ashina, Håkan; Schytz, Henrik Winther; Ashina, Messoud.
Calcitonin Gene-Related Peptide (CGRP) Mechanisms. red. / S. Brian; P. Geppetti. Bind 255 Springer, 2019. s. 109-120 (Handbook of Experimental Pharmacology).Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - CGRP in Human Models of Migraine
AU - Ashina, Håkan
AU - Schytz, Henrik Winther
AU - Ashina, Messoud
PY - 2019
Y1 - 2019
N2 - Over the past three decades, calcitonin gene-related peptide (CGRP) has emerged as a key molecule. Provocation experiments have demonstrated that intravenous CGRP infusion induces migraine-like attacks in migraine with and without aura patients. In addition, these studies have revealed a heterogeneous CGRP response, i.e., some migraine patients develop migraine-like attacks after CGRP infusion, while others do not. The role of CGRP in human migraine models has pointed to three potential sites of CGRP-induced migraine: (1) vasodilation via cyclic adenosine monophosphate (cAMP) and possibly cyclic guanosine monophosphate (cGMP); (2) activation of trigeminal sensory afferents, and (3) modulation of deep brain structures. In the future, refined human experimental studies will continue to unveil the role of CGRP in migraine pathogenesis.
AB - Over the past three decades, calcitonin gene-related peptide (CGRP) has emerged as a key molecule. Provocation experiments have demonstrated that intravenous CGRP infusion induces migraine-like attacks in migraine with and without aura patients. In addition, these studies have revealed a heterogeneous CGRP response, i.e., some migraine patients develop migraine-like attacks after CGRP infusion, while others do not. The role of CGRP in human migraine models has pointed to three potential sites of CGRP-induced migraine: (1) vasodilation via cyclic adenosine monophosphate (cAMP) and possibly cyclic guanosine monophosphate (cGMP); (2) activation of trigeminal sensory afferents, and (3) modulation of deep brain structures. In the future, refined human experimental studies will continue to unveil the role of CGRP in migraine pathogenesis.
KW - Calcitonin/pharmacology
KW - Calcitonin Gene-Related Peptide/genetics
KW - Cyclic AMP
KW - Cyclic GMP
KW - Humans
KW - Migraine Disorders/therapy
U2 - 10.1007/164_2018_128
DO - 10.1007/164_2018_128
M3 - Book chapter
C2 - 29896653
SN - 978-3-030-21453-1
VL - 255
T3 - Handbook of Experimental Pharmacology
SP - 109
EP - 120
BT - Calcitonin Gene-Related Peptide (CGRP) Mechanisms
A2 - Brian, S.
A2 - Geppetti, P.
PB - Springer
ER -
ID: 233589735