TY - JOUR

T1 - Cerebral metabolism in a case of multiple sclerosis with acute mental disorder

AU - Blinkenberg, M

AU - Rune, K

AU - Jønsson, A

AU - Holm, S

AU - Jensen, C V

AU - Paulson, O B

AU - Sørensen, P S

PY - 1996/11

Y1 - 1996/11

N2 - Acute mental disorder in early Multiple Sclerosis (MS) is rare and little is known about the structural and metabolic changes in this relation. We present an MS patient with discrete motor and sensory deficits, who developed severe behavioral changes over a period of nine months during the initial course of the disease. The cerebral metabolic rate of glucose (CMRglc) was measured using positron emission tomography (PET), and the patient underwent MRI as well as a comprehensive battery of neuropsychological tests. Significantly reduced values of CMRglc were found bilaterally in the frontal and temporal cortex, the putamen, the thalamus and the hippocampus. The MRI revealed progression of MS lesions in the frontal lobes during the development of mental symptoms. Neuropsychological examination showed wide spread cognitive dysfunction, and a pronounced frontal lobe syndrome. The study demonstrates the remote metabolic effects of lesions affecting subcortical neural connections in an MS patient with severe cognitive dysfunction.

AB - Acute mental disorder in early Multiple Sclerosis (MS) is rare and little is known about the structural and metabolic changes in this relation. We present an MS patient with discrete motor and sensory deficits, who developed severe behavioral changes over a period of nine months during the initial course of the disease. The cerebral metabolic rate of glucose (CMRglc) was measured using positron emission tomography (PET), and the patient underwent MRI as well as a comprehensive battery of neuropsychological tests. Significantly reduced values of CMRglc were found bilaterally in the frontal and temporal cortex, the putamen, the thalamus and the hippocampus. The MRI revealed progression of MS lesions in the frontal lobes during the development of mental symptoms. Neuropsychological examination showed wide spread cognitive dysfunction, and a pronounced frontal lobe syndrome. The study demonstrates the remote metabolic effects of lesions affecting subcortical neural connections in an MS patient with severe cognitive dysfunction.

KW - Acute Disease

KW - Adult

KW - Brain/metabolism

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Mental Disorders/diagnostic imaging

KW - Multiple Sclerosis/complications

KW - Neuropsychological Tests

KW - Tomography, Emission-Computed

U2 - 10.1111/j.1600-0404.1996.tb07071.x

DO - 10.1111/j.1600-0404.1996.tb07071.x

M3 - Journal article

C2 - 8947281

VL - 94

SP - 310

EP - 313

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

IS - 5

ER -