Carbon-14 bomb pulse dating shows that tendinopathy is preceded by years of abnormally high collagen turnover
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Carbon-14 bomb pulse dating shows that tendinopathy is preceded by years of abnormally high collagen turnover. / Heinemeier, Katja Maria; Schjerling, Peter; Øhlenschlæger, Tommy F; Eismark, Christian; Olsen, Jesper; Kjær, Michael.
I: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Bind 32, Nr. 9, 09.2018, s. 4763-4775.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Carbon-14 bomb pulse dating shows that tendinopathy is preceded by years of abnormally high collagen turnover
AU - Heinemeier, Katja Maria
AU - Schjerling, Peter
AU - Øhlenschlæger, Tommy F
AU - Eismark, Christian
AU - Olsen, Jesper
AU - Kjær, Michael
PY - 2018/9
Y1 - 2018/9
N2 - Tendons are essential weight-bearing structures that are often affected by tendinopathy, which leads to pain and impaired mobility. In healthy Achilles tendons, no significant renewal of the weight-bearing collagen matrix seems to occur during adult life, but tendinopathy may lead to increased turnover. The carbon-14 ([14C]) bomb pulse method was used to measure lifelong replacement rates of collagen in tendinopathic and healthy Achilles tendons (tendinopathic: n = 25, born 1937-1972. Healthy: n = 10, born 1929-1966). As expected, the healthy tendon collagen had not been replaced during adulthood, but in tendinopathic tendon, a substantial renewal had occurred. Modeling of the [14C] data suggested that one half of the collagen in tendinopathic matrix had undergone continuous slow turnover for years before the presentation of symptoms. This finding allows for a new concept in tendon pathogenesis because it suggests that either the symptoms of tendinopathy represent a late phase of a very prolonged disease process, or an abnormally high collagen exchange could be a risk factor for tendon disorders rather than being a result of disease.-Heinemeier, K. M., Schjerling, P., Øhlenschlæger, T. F., Eismark, C., Olsen, J., Kjær, M. Carbon-14 bomb pulse dating shows that tendinopathy is preceded by years of abnormally high collagen turnover.
AB - Tendons are essential weight-bearing structures that are often affected by tendinopathy, which leads to pain and impaired mobility. In healthy Achilles tendons, no significant renewal of the weight-bearing collagen matrix seems to occur during adult life, but tendinopathy may lead to increased turnover. The carbon-14 ([14C]) bomb pulse method was used to measure lifelong replacement rates of collagen in tendinopathic and healthy Achilles tendons (tendinopathic: n = 25, born 1937-1972. Healthy: n = 10, born 1929-1966). As expected, the healthy tendon collagen had not been replaced during adulthood, but in tendinopathic tendon, a substantial renewal had occurred. Modeling of the [14C] data suggested that one half of the collagen in tendinopathic matrix had undergone continuous slow turnover for years before the presentation of symptoms. This finding allows for a new concept in tendon pathogenesis because it suggests that either the symptoms of tendinopathy represent a late phase of a very prolonged disease process, or an abnormally high collagen exchange could be a risk factor for tendon disorders rather than being a result of disease.-Heinemeier, K. M., Schjerling, P., Øhlenschlæger, T. F., Eismark, C., Olsen, J., Kjær, M. Carbon-14 bomb pulse dating shows that tendinopathy is preceded by years of abnormally high collagen turnover.
U2 - 10.1096/fj.201701569R
DO - 10.1096/fj.201701569R
M3 - Journal article
C2 - 29570396
VL - 32
SP - 4763
EP - 4775
JO - F A S E B Journal
JF - F A S E B Journal
SN - 0892-6638
IS - 9
ER -
ID: 202027189