Canine induced pluripotent stem cells

Canine induced pluripotent stem cells: An in vitro approach to validate the dog as a large animal model for Alzheimer’s disease

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Standard

Canine induced pluripotent stem cells : An in vitro approach to validate the dog as a large animal model for Alzheimer’s disease. / De Figueiredo Pessôa, Laís Vicari; Chandrasekaran, Abinaya; Thomsen, Barbara Blicher; Berendt, Mette; Hyttel, Poul; Freude, Kristine.

iPSCs from Diverse Species. Academic Press, 2020. s. 77-91.

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Harvard

De Figueiredo Pessôa, LV, Chandrasekaran, A, Thomsen, BB, Berendt, M, Hyttel, P & Freude, K 2020, Canine induced pluripotent stem cells: An in vitro approach to validate the dog as a large animal model for Alzheimer’s disease. i iPSCs from Diverse Species. Academic Press, s. 77-91. https://doi.org/10.1016/B978-0-12-822228-7.00010-2

APA

De Figueiredo Pessôa, L. V., Chandrasekaran, A., Thomsen, B. B., Berendt, M., Hyttel, P., & Freude, K. (2020). Canine induced pluripotent stem cells: An in vitro approach to validate the dog as a large animal model for Alzheimer’s disease. I iPSCs from Diverse Species (s. 77-91). Academic Press. https://doi.org/10.1016/B978-0-12-822228-7.00010-2

Vancouver

De Figueiredo Pessôa LV, Chandrasekaran A, Thomsen BB, Berendt M, Hyttel P, Freude K. Canine induced pluripotent stem cells: An in vitro approach to validate the dog as a large animal model for Alzheimer’s disease. I iPSCs from Diverse Species. Academic Press. 2020. s. 77-91 https://doi.org/10.1016/B978-0-12-822228-7.00010-2

Author

De Figueiredo Pessôa, Laís Vicari ; Chandrasekaran, Abinaya ; Thomsen, Barbara Blicher ; Berendt, Mette ; Hyttel, Poul ; Freude, Kristine. / Canine induced pluripotent stem cells : An in vitro approach to validate the dog as a large animal model for Alzheimer’s disease. iPSCs from Diverse Species. Academic Press, 2020. s. 77-91

Bibtex

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title = "Canine induced pluripotent stem cells: An in vitro approach to validate the dog as a large animal model for Alzheimer{\textquoteright}s disease",

abstract = "Canine cognitive dysfunction (CCD) is a potential natural model for human Alzheimer{\textquoteright}s disease (AD). In this chapter we are addressing the current procedures of how to obtain canine induced pluripotent stem cells (ciPSCs) from geriatric dogs and the available protocols for differentiation of ciPSC into neurons. Moreover, we present how these neurons derived from ciPSC can be compared to human iPSC (hiPSC)-derived neurons in order to validate dogs with CCD as natural models for AD. This practical example presents the importance to generate species-specific iPSC to broaden our knowledge of cell type-specific disease models and to investigate, compare, and evaluate the different animal models as appropriate disease models for human diseases.",

keywords = "Cellular, Clinical trial, Cognitive dysfunction, Comparative study, Dementia, Development, Differentiation, Disease model, Dog, Drugs, Fibroblast, iPSC, Neural induction, Pluripotency, Progenitor cells, Reprogramming",

author = "{De Figueiredo Pess{\^o}a}, {La{\'i}s Vicari} and Abinaya Chandrasekaran and Thomsen, {Barbara Blicher} and Mette Berendt and Poul Hyttel and Kristine Freude",

year = "2020",

doi = "10.1016/B978-0-12-822228-7.00010-2",

language = "English",

pages = "77--91",

booktitle = "iPSCs from Diverse Species",

publisher = "Academic Press",

address = "United States",

}

RIS

TY - CHAP

T1 - Canine induced pluripotent stem cells

T2 - An in vitro approach to validate the dog as a large animal model for Alzheimer’s disease

AU - De Figueiredo Pessôa, Laís Vicari

AU - Chandrasekaran, Abinaya

AU - Thomsen, Barbara Blicher

AU - Berendt, Mette

AU - Hyttel, Poul

AU - Freude, Kristine

PY - 2020

Y1 - 2020

N2 - Canine cognitive dysfunction (CCD) is a potential natural model for human Alzheimer’s disease (AD). In this chapter we are addressing the current procedures of how to obtain canine induced pluripotent stem cells (ciPSCs) from geriatric dogs and the available protocols for differentiation of ciPSC into neurons. Moreover, we present how these neurons derived from ciPSC can be compared to human iPSC (hiPSC)-derived neurons in order to validate dogs with CCD as natural models for AD. This practical example presents the importance to generate species-specific iPSC to broaden our knowledge of cell type-specific disease models and to investigate, compare, and evaluate the different animal models as appropriate disease models for human diseases.

AB - Canine cognitive dysfunction (CCD) is a potential natural model for human Alzheimer’s disease (AD). In this chapter we are addressing the current procedures of how to obtain canine induced pluripotent stem cells (ciPSCs) from geriatric dogs and the available protocols for differentiation of ciPSC into neurons. Moreover, we present how these neurons derived from ciPSC can be compared to human iPSC (hiPSC)-derived neurons in order to validate dogs with CCD as natural models for AD. This practical example presents the importance to generate species-specific iPSC to broaden our knowledge of cell type-specific disease models and to investigate, compare, and evaluate the different animal models as appropriate disease models for human diseases.

KW - Cellular

KW - Clinical trial

KW - Cognitive dysfunction

KW - Comparative study

KW - Dementia

KW - Development

KW - Differentiation

KW - Disease model

KW - Dog

KW - Drugs

KW - Fibroblast

KW - iPSC

KW - Neural induction

KW - Pluripotency

KW - Progenitor cells

KW - Reprogramming

U2 - 10.1016/B978-0-12-822228-7.00010-2

DO - 10.1016/B978-0-12-822228-7.00010-2

M3 - Book chapter

AN - SCOPUS:85147601464

SP - 77

EP - 91

BT - iPSCs from Diverse Species

PB - Academic Press

ER -

ID: 337997274