Can varying flow velocity across an arterial anastomosis prevent thromboembolic injury?
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Can varying flow velocity across an arterial anastomosis prevent thromboembolic injury? / Barker, J H; Andresen, D M; Anderson, G L; Schuschke, D; Gu, J M; Gupta, S; Hjortdal, V E; Derr, J W; Banis, J C; Acland, R D.
I: Microsurgery, Bind 16, Nr. 5, 1995, s. 349-56.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Can varying flow velocity across an arterial anastomosis prevent thromboembolic injury?
AU - Barker, J H
AU - Andresen, D M
AU - Anderson, G L
AU - Schuschke, D
AU - Gu, J M
AU - Gupta, S
AU - Hjortdal, V E
AU - Derr, J W
AU - Banis, J C
AU - Acland, R D
PY - 1995
Y1 - 1995
N2 - In this study, simulated "poor" repairs applied to transverse incisions in the iliac arteries of 40 rats were the basis for comparing the effect of variations in blood flow on thromboembolism. Using vital microscopy and digital image processing, we performed 2 experiments. In the first experiment (n = 20), the reduction of post-repair blood flow by approximately 50% resulted in an 83% reduction in the total number of emboli appearing in the microcirculation of the cremaster muscle distal to the repair. In the second experiment (n = 20), the same reduction in blood flow typically resulted in larger repair-site thrombi which required significantly more time to grow to their maximum size. We conclude that reducing pedicle artery blood flow to approximately half in our rat model during reperfusion can protect the downstream microcirculation from embolic injury without increasing the incidence of thrombotic occlusion.
AB - In this study, simulated "poor" repairs applied to transverse incisions in the iliac arteries of 40 rats were the basis for comparing the effect of variations in blood flow on thromboembolism. Using vital microscopy and digital image processing, we performed 2 experiments. In the first experiment (n = 20), the reduction of post-repair blood flow by approximately 50% resulted in an 83% reduction in the total number of emboli appearing in the microcirculation of the cremaster muscle distal to the repair. In the second experiment (n = 20), the same reduction in blood flow typically resulted in larger repair-site thrombi which required significantly more time to grow to their maximum size. We conclude that reducing pedicle artery blood flow to approximately half in our rat model during reperfusion can protect the downstream microcirculation from embolic injury without increasing the incidence of thrombotic occlusion.
KW - Anastomosis, Surgical
KW - Animals
KW - Blood Flow Velocity
KW - Male
KW - Microcirculation
KW - Microsurgery
KW - Postoperative Complications/prevention & control
KW - Rats
KW - Rats, Sprague-Dawley
KW - Regional Blood Flow
KW - Reperfusion/methods
KW - Surgical Flaps/physiology
KW - Thromboembolism/prevention & control
U2 - 10.1002/micr.1920160512
DO - 10.1002/micr.1920160512
M3 - Journal article
C2 - 7565027
VL - 16
SP - 349
EP - 356
JO - International Journal of Microsurgery
JF - International Journal of Microsurgery
SN - 0738-1085
IS - 5
ER -
ID: 244046832