Calcium and vitamin D homoeostasis in male fertility
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Calcium and vitamin D homoeostasis in male fertility. / Yahyavi, Sam Kafai; Boisen, Ida Marie; Cui, Zhihui; Jorsal, Mads Joon; Kooij, Ireen; Holt, Rune; Juul, Anders; Blomberg Jensen, Martin.
I: Proceedings of the Nutrition Society, Bind 83, Nr. 2, 2024, s. 95-108.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Calcium and vitamin D homoeostasis in male fertility
AU - Yahyavi, Sam Kafai
AU - Boisen, Ida Marie
AU - Cui, Zhihui
AU - Jorsal, Mads Joon
AU - Kooij, Ireen
AU - Holt, Rune
AU - Juul, Anders
AU - Blomberg Jensen, Martin
PY - 2024
Y1 - 2024
N2 - Calcium and vitamin D have well-established roles in maintaining calcium balance and bone health. Decades of research in human subjects and animals have revealed that calcium and vitamin D also have effects on many other organs including male reproductive organs. The presence of calcium-sensing receptor, vitamin D receptor, vitamin D activating and inactivating enzymes and calcium channels in the testes, male reproductive tract and human spermatozoa suggests that vitamin D and calcium may modify male reproductive function. Functional animal models have shown that vitamin D deficiency in male rodents leads to a decrease in successful mating and fewer pregnancies, often caused by impaired sperm motility and poor sperm morphology. Human studies have to a lesser extent validated these findings; however, newer studies suggest a positive effect of vitamin D supplementation on semen quality in cases with vitamin D deficiency, which highlights the need for initiatives to prevent vitamin D deficiency. Calcium channels in male reproductive organs and spermatozoa contribute to the regulation of sperm motility and capacitation, both essential for successful fertilisation, which supports a need to avoid calcium deficiency. Studies have demonstrated that vitamin D, as a regulator of calcium homoeostasis, influences calcium influx in the testis and spermatozoa. Emerging evidence suggests a potential link between vitamin D deficiency and male infertility, although further investigation is needed to establish a definitive causal relationship. Understanding the interplay between vitamin D, calcium and male reproductive health may open new avenues for improving fertility outcomes in men.
AB - Calcium and vitamin D have well-established roles in maintaining calcium balance and bone health. Decades of research in human subjects and animals have revealed that calcium and vitamin D also have effects on many other organs including male reproductive organs. The presence of calcium-sensing receptor, vitamin D receptor, vitamin D activating and inactivating enzymes and calcium channels in the testes, male reproductive tract and human spermatozoa suggests that vitamin D and calcium may modify male reproductive function. Functional animal models have shown that vitamin D deficiency in male rodents leads to a decrease in successful mating and fewer pregnancies, often caused by impaired sperm motility and poor sperm morphology. Human studies have to a lesser extent validated these findings; however, newer studies suggest a positive effect of vitamin D supplementation on semen quality in cases with vitamin D deficiency, which highlights the need for initiatives to prevent vitamin D deficiency. Calcium channels in male reproductive organs and spermatozoa contribute to the regulation of sperm motility and capacitation, both essential for successful fertilisation, which supports a need to avoid calcium deficiency. Studies have demonstrated that vitamin D, as a regulator of calcium homoeostasis, influences calcium influx in the testis and spermatozoa. Emerging evidence suggests a potential link between vitamin D deficiency and male infertility, although further investigation is needed to establish a definitive causal relationship. Understanding the interplay between vitamin D, calcium and male reproductive health may open new avenues for improving fertility outcomes in men.
U2 - 10.1017/S002966512300486X
DO - 10.1017/S002966512300486X
M3 - Review
C2 - 38072394
VL - 83
SP - 95
EP - 108
JO - Proceedings of the Nutrition Society
JF - Proceedings of the Nutrition Society
SN - 0029-6651
IS - 2
T2 - The Nutrition Society Irish Section Conference 2023
Y2 - 14 June 2023 through 16 June 2023
ER -
ID: 387110088