Bridging microscopic cell dynamics to nematohydrodynamics of cell monolayers
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
It is increasingly being realized that liquid-crystalline features can play an important role in the properties and dynamics of cell monolayers. Here, we present a cell-based model of cell layers, based on the phase-field formulation, that connects cell-cell interactions specified at the single cell level to large-scale nematic and hydrodynamic properties of the tissue. In particular, we present a minimal formulation that reproduces the well-known bend and splay hydrodynamic instabilities of the continuum nemato-hydrodynamic formulation of active matter, together with an analytical description of the instability threshold in terms of activity and elasticity of the cells. Furthermore, we provide a quantitative characterisation and comparison of flows and topological defects for extensile and contractile stress generation mechanisms, and demonstrate activity-induced heterogeneity and spontaneous formation of gaps within a confluent monolayer. Together, these results contribute to bridging the gap between cell-scale dynamics and tissue-scale collective cellular organisation.
Originalsprog | Engelsk |
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Tidsskrift | Soft Matter |
Vol/bind | 18 |
Udgave nummer | 25 |
Sider (fra-til) | 4737-4746 |
Antal sider | 10 |
ISSN | 1744-683X |
DOI | |
Status | Udgivet - 29 jun. 2022 |
Links
- https://arxiv.org/pdf/2204.12994.pdf
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