Breast cancer after bilateral risk-reducing mastectomy
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Breast cancer after bilateral risk-reducing mastectomy. / Skytte, A-B; Crüger, Dorthe Gylling; Gerster, M; Laenkholm, A-V; Lang, C; Brøndum-Nielsen, K; Andersen, M K; Sunde, Lone E. M.; Kølvraa, Steen; Gerdes, A-M.
I: Clinical Genetics, Bind 79, Nr. 5, 2011, s. 431-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Breast cancer after bilateral risk-reducing mastectomy
AU - Skytte, A-B
AU - Crüger, Dorthe Gylling
AU - Gerster, M
AU - Laenkholm, A-V
AU - Lang, C
AU - Brøndum-Nielsen, K
AU - Andersen, M K
AU - Sunde, Lone E. M.
AU - Kølvraa, Steen
AU - Gerdes, A-M
N1 - © 2011 John Wiley & Sons A/S.
PY - 2011
Y1 - 2011
N2 - This study aims to evaluate the incidence of breast cancer after risk-reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long-term follow-up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk-reducing bilateral salpingo-oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post-mastectomy breast cancer was 0.8% compared with 1.7% in the non-operated group. Implications of these findings in relation to genetic counseling and future management are discussed.
AB - This study aims to evaluate the incidence of breast cancer after risk-reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long-term follow-up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk-reducing bilateral salpingo-oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post-mastectomy breast cancer was 0.8% compared with 1.7% in the non-operated group. Implications of these findings in relation to genetic counseling and future management are discussed.
U2 - 10.1111/j.1399-0004.2010.01604.x
DO - 10.1111/j.1399-0004.2010.01604.x
M3 - Journal article
C2 - 21199491
VL - 79
SP - 431
EP - 437
JO - Clinical Genetics
JF - Clinical Genetics
SN - 0009-9163
IS - 5
ER -
ID: 33504058