Brain ventricular dimensions and relationship to outcome in adult patients with bacterial meningitis
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Brain ventricular dimensions and relationship to outcome in adult patients with bacterial meningitis. / Sporrborn, Janni L; Knudsen, Gertrud B; Sølling, Mette; Seierøe, Karina; Farre, Annette; Lindhardt, Bjarne Ø; Benfield, Thomas; Brandt, Christian T.
I: B M C Infectious Diseases, Bind 15, 367, 2015, s. 1-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Brain ventricular dimensions and relationship to outcome in adult patients with bacterial meningitis
AU - Sporrborn, Janni L
AU - Knudsen, Gertrud B
AU - Sølling, Mette
AU - Seierøe, Karina
AU - Farre, Annette
AU - Lindhardt, Bjarne Ø
AU - Benfield, Thomas
AU - Brandt, Christian T
PY - 2015
Y1 - 2015
N2 - BACKGROUND: Experimental studies suggest that changes in brain ventricle size are key events in bacterial meningitis. This study investigated the relationship between ventricle size, clinical condition and risk of poor outcome in patients with bacterial meningitis.METHODS: Adult patients diagnosed with bacterial meningitis admitted to two departments of infectious diseases from 2003 through 2010 were identified. Clinical and biochemical data as well as cerebral computed tomographic images were collected. The size of the brain ventricles were presented as a Ventricle to Brain Ratio (VBR). Normal range of VBR was defined from an age matched control group. A multivariate analysis was performed to identify predictors of 30-day mortality.RESULTS: One hundred and seven patients were included. Eighty-one patients had a CT scan at the time of diagnosis. VBR was identified as an independent risk factor of 30-day mortality, Mortality Rate Ratio: 6.03 (95 % confidence interval: 1.61-22.64, p = 0.008) for highest versus lowest tertile. A VBR deviating more than 2 standard deviations from the normal range was associated with increased mortality.CONCLUSIONS: Brain ventricles are commonly subject to marked changes in size as a consequence of meningitis. Increased brain ventricle size in the acute phase of bacterial meningitis was associated with increased mortality.
AB - BACKGROUND: Experimental studies suggest that changes in brain ventricle size are key events in bacterial meningitis. This study investigated the relationship between ventricle size, clinical condition and risk of poor outcome in patients with bacterial meningitis.METHODS: Adult patients diagnosed with bacterial meningitis admitted to two departments of infectious diseases from 2003 through 2010 were identified. Clinical and biochemical data as well as cerebral computed tomographic images were collected. The size of the brain ventricles were presented as a Ventricle to Brain Ratio (VBR). Normal range of VBR was defined from an age matched control group. A multivariate analysis was performed to identify predictors of 30-day mortality.RESULTS: One hundred and seven patients were included. Eighty-one patients had a CT scan at the time of diagnosis. VBR was identified as an independent risk factor of 30-day mortality, Mortality Rate Ratio: 6.03 (95 % confidence interval: 1.61-22.64, p = 0.008) for highest versus lowest tertile. A VBR deviating more than 2 standard deviations from the normal range was associated with increased mortality.CONCLUSIONS: Brain ventricles are commonly subject to marked changes in size as a consequence of meningitis. Increased brain ventricle size in the acute phase of bacterial meningitis was associated with increased mortality.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Brain
KW - Cerebral Ventricles
KW - Denmark
KW - Female
KW - Humans
KW - Male
KW - Meningitis, Bacterial
KW - Middle Aged
KW - Multivariate Analysis
KW - Retrospective Studies
KW - Risk Factors
KW - Survival Analysis
KW - Tomography, X-Ray Computed
U2 - 10.1186/s12879-015-1097-3
DO - 10.1186/s12879-015-1097-3
M3 - Journal article
C2 - 26303023
VL - 15
SP - 1
EP - 9
JO - B M C Infectious Diseases
JF - B M C Infectious Diseases
SN - 1471-2334
M1 - 367
ER -
ID: 161949742