Brain structural changes in blindness: a systematic review and an anatomical likelihood estimation (ALE) meta-analysis
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Brain structural changes in blindness : a systematic review and an anatomical likelihood estimation (ALE) meta-analysis. / Paré, Samuel; Bleau, Maxime; Dricot, Laurence; Ptito, Maurice; Kupers, Ron.
I: Neuroscience and Biobehavioral Reviews, Bind 150, 105165, 2023.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Brain structural changes in blindness
T2 - a systematic review and an anatomical likelihood estimation (ALE) meta-analysis
AU - Paré, Samuel
AU - Bleau, Maxime
AU - Dricot, Laurence
AU - Ptito, Maurice
AU - Kupers, Ron
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023
Y1 - 2023
N2 - In recent decades, numerous structural brain imaging studies investigated purported morphometric changes in early (EB) and late onset blindness (LB). The results of these studies have not yielded very consistent results, neither with respect to the type, nor to the anatomical locations of the brain morphometric alterations. To better characterize the effects of blindness on brain morphometry, we performed a systematic review and an Anatomical-Likelihood-Estimation (ALE) coordinate-based-meta-analysis of 65 eligible studies on brain structural changes in EB and LB, including 890 EB, 466 LB and 1257 sighted controls. Results revealed atrophic changes throughout the whole extent of the retino-geniculo-striate system in both EB and LB, whereas changes in areas beyond the occipital lobe occurred in EB only. We discuss the nature of some of the contradictory findings with respect to the used brain imaging methodologies and characteristics of the blind populations such as the onset, duration and cause of blindness. Future studies should aim for much larger sample sizes, eventually by merging data from different brain imaging centers using the same imaging sequences, opt for multimodal structural brain imaging, and go beyond a purely structural approach by combining functional with structural connectivity network analyses.
AB - In recent decades, numerous structural brain imaging studies investigated purported morphometric changes in early (EB) and late onset blindness (LB). The results of these studies have not yielded very consistent results, neither with respect to the type, nor to the anatomical locations of the brain morphometric alterations. To better characterize the effects of blindness on brain morphometry, we performed a systematic review and an Anatomical-Likelihood-Estimation (ALE) coordinate-based-meta-analysis of 65 eligible studies on brain structural changes in EB and LB, including 890 EB, 466 LB and 1257 sighted controls. Results revealed atrophic changes throughout the whole extent of the retino-geniculo-striate system in both EB and LB, whereas changes in areas beyond the occipital lobe occurred in EB only. We discuss the nature of some of the contradictory findings with respect to the used brain imaging methodologies and characteristics of the blind populations such as the onset, duration and cause of blindness. Future studies should aim for much larger sample sizes, eventually by merging data from different brain imaging centers using the same imaging sequences, opt for multimodal structural brain imaging, and go beyond a purely structural approach by combining functional with structural connectivity network analyses.
KW - Brain morphometry
KW - Cross-modal plasticity
KW - Early and late onset blindness
KW - Grey matter, white matter
KW - MRI, DTI
KW - Visual system
U2 - 10.1016/j.neubiorev.2023.105165
DO - 10.1016/j.neubiorev.2023.105165
M3 - Review
C2 - 37054803
AN - SCOPUS:85157971044
VL - 150
JO - Neuroscience & Biobehavioral Reviews
JF - Neuroscience & Biobehavioral Reviews
SN - 0149-7634
M1 - 105165
ER -
ID: 346953124