Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure

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Standard

Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. / Bjerring, Peter Nissen; Hauerberg, John; Jørgensen, Linda; Frederiksen, Hans-Jørgen; Tofteng, Flemming; Hansen, Bent Adel; Larsen, Fin Stolze.

I: Journal of Hepatology, Bind 53, Nr. 6, 01.12.2010, s. 1054-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bjerring, PN, Hauerberg, J, Jørgensen, L, Frederiksen, H-J, Tofteng, F, Hansen, BA & Larsen, FS 2010, 'Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure', Journal of Hepatology, bind 53, nr. 6, s. 1054-8. https://doi.org/10.1016/j.jhep.2010.05.032

APA

Bjerring, P. N., Hauerberg, J., Jørgensen, L., Frederiksen, H-J., Tofteng, F., Hansen, B. A., & Larsen, F. S. (2010). Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. Journal of Hepatology, 53(6), 1054-8. https://doi.org/10.1016/j.jhep.2010.05.032

Vancouver

Bjerring PN, Hauerberg J, Jørgensen L, Frederiksen H-J, Tofteng F, Hansen BA o.a. Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. Journal of Hepatology. 2010 dec. 1;53(6):1054-8. https://doi.org/10.1016/j.jhep.2010.05.032

Author

Bjerring, Peter Nissen ; Hauerberg, John ; Jørgensen, Linda ; Frederiksen, Hans-Jørgen ; Tofteng, Flemming ; Hansen, Bent Adel ; Larsen, Fin Stolze. / Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. I: Journal of Hepatology. 2010 ; Bind 53, Nr. 6. s. 1054-8.

Bibtex

@article{8e6fb91e5ccb436ca258f557ed6f0248,

title = "Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure",

abstract = "The pathogenesis of cerebral edema in acute liver failure is suggested, in in vitro and animal studies, to involve a compromised oxidative metabolism with a decrease in cerebral ATP levels and an increase in purine concentrations. In this study we hypothesize that the cerebral concentrations of hypoxanthine, inosine, and lactate/pyruvate (LP) ratio are increased and correlated in patients with acute liver failure. Furthermore, we expect the purines and L/P ratio to correlate with intracranial pressure (ICP) (positively), and cerebral perfusion pressure (CPP) (negatively).",

author = "Bjerring, {Peter Nissen} and John Hauerberg and Linda J{\o}rgensen and Hans-J{\o}rgen Frederiksen and Flemming Tofteng and Hansen, {Bent Adel} and Larsen, {Fin Stolze}",

year = "2010",

month = dec,

day = "1",

doi = "http://dx.doi.org/10.1016/j.jhep.2010.05.032",

language = "English",

volume = "53",

pages = "1054--8",

journal = "Journal of Hepatology, Supplement",

issn = "0169-5185",

publisher = "Elsevier",

number = "6",

}

RIS

TY - JOUR

T1 - Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure

AU - Bjerring, Peter Nissen

AU - Hauerberg, John

AU - Jørgensen, Linda

AU - Frederiksen, Hans-Jørgen

AU - Tofteng, Flemming

AU - Hansen, Bent Adel

AU - Larsen, Fin Stolze

PY - 2010/12/1

Y1 - 2010/12/1

N2 - The pathogenesis of cerebral edema in acute liver failure is suggested, in in vitro and animal studies, to involve a compromised oxidative metabolism with a decrease in cerebral ATP levels and an increase in purine concentrations. In this study we hypothesize that the cerebral concentrations of hypoxanthine, inosine, and lactate/pyruvate (LP) ratio are increased and correlated in patients with acute liver failure. Furthermore, we expect the purines and L/P ratio to correlate with intracranial pressure (ICP) (positively), and cerebral perfusion pressure (CPP) (negatively).

AB - The pathogenesis of cerebral edema in acute liver failure is suggested, in in vitro and animal studies, to involve a compromised oxidative metabolism with a decrease in cerebral ATP levels and an increase in purine concentrations. In this study we hypothesize that the cerebral concentrations of hypoxanthine, inosine, and lactate/pyruvate (LP) ratio are increased and correlated in patients with acute liver failure. Furthermore, we expect the purines and L/P ratio to correlate with intracranial pressure (ICP) (positively), and cerebral perfusion pressure (CPP) (negatively).

U2 - http://dx.doi.org/10.1016/j.jhep.2010.05.032

DO - http://dx.doi.org/10.1016/j.jhep.2010.05.032

M3 - Journal article

VL - 53

SP - 1054

EP - 1058

JO - Journal of Hepatology, Supplement

JF - Journal of Hepatology, Supplement

SN - 0169-5185

IS - 6

ER -

ID: 34074302