TY - JOUR

T1 - Bone From Blood

T2 - Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells

AU - Feehan, Jack

AU - Kassem, Moustapha

AU - Pignolo, Robert J.

AU - Duque, Gustavo

PY - 2021

Y1 - 2021

N2 - Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases.

AB - Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases.

KW - CIRCULATING OSTEOGENIC PRECURSOR CELLS

KW - COP CELLS

KW - FRACTURE

KW - FRAILTY

KW - HETEROTOPIC OSSIFICATION

KW - OSTEOPOROSIS

KW - VASCULAR CALCIFICATION

U2 - 10.1002/jbmr.4204

DO - 10.1002/jbmr.4204

M3 - Review

C2 - 33118647

AN - SCOPUS:85096761725

VL - 36

SP - 12

EP - 23

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 1

ER -