Blood-Biomarkers for Glucose Metabolism in Preterm Infants
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Blood-Biomarkers for Glucose Metabolism in Preterm Infants. / Bjerager, Mia O.; Hansen, Bo M.; Sørensen, Frederik; Petersen, Jes R.; Jensen, Kristian V.; Hjelvang, Brian R.; Hvelplund, Anna C.; Olsen, Dorte A.; Nielsen, Aneta A.; Forman, Julie L.; Brandslund, Ivan; Greisen, Gorm; Slidsborg, Carina.
I: Biomedicines, Bind 11, Nr. 9, 2377, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Blood-Biomarkers for Glucose Metabolism in Preterm Infants
AU - Bjerager, Mia O.
AU - Hansen, Bo M.
AU - Sørensen, Frederik
AU - Petersen, Jes R.
AU - Jensen, Kristian V.
AU - Hjelvang, Brian R.
AU - Hvelplund, Anna C.
AU - Olsen, Dorte A.
AU - Nielsen, Aneta A.
AU - Forman, Julie L.
AU - Brandslund, Ivan
AU - Greisen, Gorm
AU - Slidsborg, Carina
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2023
Y1 - 2023
N2 - This was an exploratory, prospective, longitudinal, cohort study that aimed to establish “healthy” reference levels related to growth parameters and glucose metabolites in preterm infants. This was conducted to further investigate growth and metabolic disturbances potentially related to neonatal illness. The study sample consisted of 108 preterm infants born before 32 weeks in 2018–2019 in the Capital Region of Denmark. Repetitive blood samples were acquired at the neonatal wards, while clinical data were obtained from the regional hospital medical record system. Thirty-four “healthy” preterm infants (31%) were identified. The “ill” infants were divided into four subgroups dependent on gestational age and small for gestational age. Reference levels for the growth parameters and metabolic biomarkers glucose, albumin, and adiponectin, and two glucose control indicators, glycated albumin and fructosamine, were determined for the “healthy” and “ill” subgroups. The “ill” extremely preterm infants had increased glucose levels (mean difference 0.71 mmol/L, 95% CI 0.23; 1.18 mmol/L) and glycated albumin (corrected; %) (mean difference 0.92 mmol/L, 95% CI 0.38 mmol/L;1.47 mmol/L) compared to the “healthy” infants. In “ill” extremely preterm infants and “ill” very preterm infants born small for gestational age, levels of biomarkers containing proteins were decreased. In the “Ill” extremely preterm infants and infants born small for gestational age, postnatal growth was continuously decreased throughout the postconceptional period. The short-term glucose-control indicator, glycated albumin (corrected; %), reflected well the high glucose levels due to its correction for the depleted plasma-protein pool.
AB - This was an exploratory, prospective, longitudinal, cohort study that aimed to establish “healthy” reference levels related to growth parameters and glucose metabolites in preterm infants. This was conducted to further investigate growth and metabolic disturbances potentially related to neonatal illness. The study sample consisted of 108 preterm infants born before 32 weeks in 2018–2019 in the Capital Region of Denmark. Repetitive blood samples were acquired at the neonatal wards, while clinical data were obtained from the regional hospital medical record system. Thirty-four “healthy” preterm infants (31%) were identified. The “ill” infants were divided into four subgroups dependent on gestational age and small for gestational age. Reference levels for the growth parameters and metabolic biomarkers glucose, albumin, and adiponectin, and two glucose control indicators, glycated albumin and fructosamine, were determined for the “healthy” and “ill” subgroups. The “ill” extremely preterm infants had increased glucose levels (mean difference 0.71 mmol/L, 95% CI 0.23; 1.18 mmol/L) and glycated albumin (corrected; %) (mean difference 0.92 mmol/L, 95% CI 0.38 mmol/L;1.47 mmol/L) compared to the “healthy” infants. In “ill” extremely preterm infants and “ill” very preterm infants born small for gestational age, levels of biomarkers containing proteins were decreased. In the “Ill” extremely preterm infants and infants born small for gestational age, postnatal growth was continuously decreased throughout the postconceptional period. The short-term glucose-control indicator, glycated albumin (corrected; %), reflected well the high glucose levels due to its correction for the depleted plasma-protein pool.
KW - blood biomarkers
KW - glucose
KW - healthy reference levels
KW - metabolism
KW - plasma-protein depletion
KW - preterm infants
U2 - 10.3390/biomedicines11092377
DO - 10.3390/biomedicines11092377
M3 - Journal article
C2 - 37760819
AN - SCOPUS:85172469829
VL - 11
JO - Biomedicines
JF - Biomedicines
SN - 2227-9059
IS - 9
M1 - 2377
ER -
ID: 368970268