Blood pressure and body composition during first year of antiretroviral therapy in people with HIV compared to HIV-uninfected community controls
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Blood pressure and body composition during first year of antiretroviral therapy in people with HIV compared to HIV-uninfected community controls. / Kavishe, Bazil Baltazar; Olsen, Mette Frahm; Filteau, Suzanne; Kitilya, Brenda Wilfred; Jeremiah, K; Krogh-Madsen, Rikke; Todd, J; Friis, Henrik; Faurholt-Jepsen, Daniel; PrayGod, G; Peck, Robert.
I: American Journal of Hypertension, Bind 35, Nr. 11, 2022, s. 929-937.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Blood pressure and body composition during first year of antiretroviral therapy in people with HIV compared to HIV-uninfected community controls
AU - Kavishe, Bazil Baltazar
AU - Olsen, Mette Frahm
AU - Filteau, Suzanne
AU - Kitilya, Brenda Wilfred
AU - Jeremiah, K
AU - Krogh-Madsen, Rikke
AU - Todd, J
AU - Friis, Henrik
AU - Faurholt-Jepsen, Daniel
AU - PrayGod, G
AU - Peck, Robert
N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2022
Y1 - 2022
N2 - Background: Body composition changes may explain the rapid increase in blood pressure (BP) in people with HIV (PWH) during the first year of antiretroviral therapy.Methods: We analyzed data from a cohort of PWH and HIV-uninfected adults from the same communities in Mwanza, Tanzania. Blood pressure (BP, mmHg) and body composition data were collected at baseline and 12 months follow-up. We used multivariable linear regression to compare BP changes in PWH and HIV-uninfected adults, and the relationship between changes in body composition and changes in BP.Results: BP data was available for 640 PWH and 299 HIV-uninfected adults. Sixty-four percent were women and the mean age was 38 years. In PWH, systolic BP (SBP) increased (114 to 118) whereas SBP decreased (125 to 123) in HIV-uninfected participants. Fat mass increased by 1.6 kilogram on average in PWH and was strongly associated with change in BP (P < 0.001). The greater increase in SBP in PWH was partly explained by the lower baseline SBP but PWH still experienced a 2.2 (95% CI: 0.3-4.2) greater increase in SBP after adjustment. Weight gain partially mediated the relationship between HIV and SBP increase in PWH; a one kilogram increase in fat mass accounted for 0.8 (95% CI: 0.6-1.1) increase in SBP.Conclusions: Weight and fat mass increase rapidly in PWH during the first 12 months of antiretroviral therapy and contribute to a rapid increase in SBP. Interventions to prevent excessive increase in fat mass are needed for PWH.
AB - Background: Body composition changes may explain the rapid increase in blood pressure (BP) in people with HIV (PWH) during the first year of antiretroviral therapy.Methods: We analyzed data from a cohort of PWH and HIV-uninfected adults from the same communities in Mwanza, Tanzania. Blood pressure (BP, mmHg) and body composition data were collected at baseline and 12 months follow-up. We used multivariable linear regression to compare BP changes in PWH and HIV-uninfected adults, and the relationship between changes in body composition and changes in BP.Results: BP data was available for 640 PWH and 299 HIV-uninfected adults. Sixty-four percent were women and the mean age was 38 years. In PWH, systolic BP (SBP) increased (114 to 118) whereas SBP decreased (125 to 123) in HIV-uninfected participants. Fat mass increased by 1.6 kilogram on average in PWH and was strongly associated with change in BP (P < 0.001). The greater increase in SBP in PWH was partly explained by the lower baseline SBP but PWH still experienced a 2.2 (95% CI: 0.3-4.2) greater increase in SBP after adjustment. Weight gain partially mediated the relationship between HIV and SBP increase in PWH; a one kilogram increase in fat mass accounted for 0.8 (95% CI: 0.6-1.1) increase in SBP.Conclusions: Weight and fat mass increase rapidly in PWH during the first 12 months of antiretroviral therapy and contribute to a rapid increase in SBP. Interventions to prevent excessive increase in fat mass are needed for PWH.
KW - Faculty of Science
KW - Blood pressure
KW - Body composition
KW - Fat mass
KW - Fat-free mass
KW - Body weight
KW - People with HIV
U2 - 10.1093/ajh/hpac085
DO - 10.1093/ajh/hpac085
M3 - Journal article
C2 - 35881168
VL - 35
SP - 929
EP - 937
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 11
ER -
ID: 315268035