Biological and environmental predictors of heterogeneity in neurocognitive ageing: Evidence from Betula and other longitudinal studies

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

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  • Lars Nyberg
  • Boraxbekk, Carl-Johan Oskar
  • Daniel Eriksson Sörman
  • Patrik Hansson
  • Agneta Herlitz
  • Karolina Kauppi
  • Jessica K. Ljungberg
  • Hugo Lövheim
  • Anders Lundquist
  • Annelie Nordin Adolfsson
  • Anna Oudin
  • Sara Pudas
  • Michael Rönnlund
  • Mikael Stiernstedt
  • Anna Sundström
  • Rolf Adolfsson

Individual differences in cognitive performance increase with advancing age, reflecting marked cognitive changes in some individuals along with little or no change in others. Genetic and lifestyle factors are assumed to influence cognitive performance in ageing by affecting the magnitude and extent of age-related brain changes (i.e., brain maintenance or atrophy), as well as the ability to recruit compensatory processes. The purpose of this review is to present findings from the Betula study and other longitudinal studies, with a focus on clarifying the role of key biological and environmental factors assumed to underlie individual differences in brain and cognitive ageing. We discuss the vital importance of sampling, analytic methods, consideration of non-ignorable dropout, and related issues for valid conclusions on factors that influence healthy neurocognitive ageing.

OriginalsprogEngelsk
Artikelnummer101184
TidsskriftAgeing Research Reviews
Vol/bind64
Antal sider23
ISSN1568-1637
DOI
StatusUdgivet - 2020
Eksternt udgivetJa

Bibliografisk note

Funding Information:
Ongoing work in the Betula project is supported by: grants from the Knut and Alice Wallenberg (KAW-scholar) Foundation , Horizon2020 (Grant agreement no: 732592 - Lifebrain - H2020-SC1-2016-2017/H2020-SC1-2016-RTD), Swedish Research Council (NEAR, The National E-infrastructure for Aging Research in Sweden Grant no 2017-00639 ) to Lars Nyberg; grants from Region Västerbotten, Wallenberg Centre for Molecular Medicine (WCMM) at Umeå University, Swedish Dementia Association , Swedish Alzheimer Fund and Umeå University Foundation for Medical Research to Hugo Lövheim ; a grant from Knut and Alice Wallenberg foundation awarded to Jessica K. Ljungberg [grant number KAW 2014.0205 ], a grant from Swedish research council for Humanities and Social Sciences (grant no 2015–02199 ) to Michael Rönnlund; a grant from Swedish Research Council (Grant no 2017-03011 ) to Karolina Kauppi; grants from the Swedish Research Council ( 2018-01729 ) and Umeå University Foundation for Medical Research to Sara Pudas , and a grant from the Swedish Research Council Formas, Stockholm, Sweden [registration number 942–2015-1099] to Maria Nordin. We warmly acknowledge the contribution to the Betula project by the participants as well as our many collaborators over the years, in particular Professor em. Lars-Göran Nilsson for his vision, commitment, and genuine passion for science.

Publisher Copyright:
© 2020 The Author(s)

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